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Body mass index and survival of patients with lymphoma
The impact of body mass index (BMI) on survival in lymphoma remains controversial. We leveraged a prospective cohort of lymphoma patients enrolled to SPORE Molecular Epidemiology Resource between 2002 and 2015 to assess the association of BMI before diagnosis, BMI at diagnosis, and BMI change over t...
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| Published in: | Leukemia & lymphoma 2021-09, Vol.62 (11), p.2671-2678 |
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| container_title | Leukemia & lymphoma |
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| creator | Chihara, Dai Larson, Melissa C. Robinson, Dennis P. Thompson, Carrie A. Maurer, Matthew J. Casulo, Carla Pophali, Priyanka Link, Brian K. Habermann, Thomas M. Feldman, Andrew L. Flowers, Christopher R. Cerhan, James R. Morton, Lindsay M. |
| description | The impact of body mass index (BMI) on survival in lymphoma remains controversial. We leveraged a prospective cohort of lymphoma patients enrolled to SPORE Molecular Epidemiology Resource between 2002 and 2015 to assess the association of BMI before diagnosis, BMI at diagnosis, and BMI change over time with lymphoma-specific survival (LSS). A total of 4009 lymphoma patients (670 diffuse large B-cell lymphoma (DLBCL), 689 follicular lymphoma (FL), 1018 chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), and 1632 other subtypes) were included. Significantly shorter LSS after diagnosis was observed for FL patients who were obese before diagnosis (HR: 3.02, 95%CI: 1.43-6.41, p=.004) and for those with a ≥ 5% increase in BMI from diagnosis to 3-year follow-up (HR: 3.53, 95%CI: 1.22-10.2, p=.020). In contrast, obesity prior to or at the time of diagnosis was not associated with LSS in DLBCL and CLL/SLL. The impact of weight control after diagnosis in FL patient warrants investigation. |
| doi_str_mv | 10.1080/10428194.2021.1929956 |
| format | article |
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We leveraged a prospective cohort of lymphoma patients enrolled to SPORE Molecular Epidemiology Resource between 2002 and 2015 to assess the association of BMI before diagnosis, BMI at diagnosis, and BMI change over time with lymphoma-specific survival (LSS). A total of 4009 lymphoma patients (670 diffuse large B-cell lymphoma (DLBCL), 689 follicular lymphoma (FL), 1018 chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), and 1632 other subtypes) were included. Significantly shorter LSS after diagnosis was observed for FL patients who were obese before diagnosis (HR: 3.02, 95%CI: 1.43-6.41, p=.004) and for those with a ≥ 5% increase in BMI from diagnosis to 3-year follow-up (HR: 3.53, 95%CI: 1.22-10.2, p=.020). In contrast, obesity prior to or at the time of diagnosis was not associated with LSS in DLBCL and CLL/SLL. The impact of weight control after diagnosis in FL patient warrants investigation.</description><identifier>ISSN: 1042-8194</identifier><identifier>EISSN: 1029-2403</identifier><identifier>DOI: 10.1080/10428194.2021.1929956</identifier><identifier>PMID: 34121594</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Body Mass Index ; CLL/SLL ; Cohort Studies ; Diffuse large B-cell lymphoma ; follicular lymphoma ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis ; Leukemia, Lymphocytic, Chronic, B-Cell - epidemiology ; Lymphoma, Follicular - diagnosis ; Lymphoma, Follicular - epidemiology ; Lymphoma, Large B-Cell, Diffuse - diagnosis ; Lymphoma, Large B-Cell, Diffuse - epidemiology ; Prospective Studies ; survival</subject><ispartof>Leukemia & lymphoma, 2021-09, Vol.62 (11), p.2671-2678</ispartof><rights>2021 Informa UK Limited, trading as Taylor & Francis Group 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-764285687f14c54ef1bfb5a960123e0ace481dc565bbdf0a6228e6534baac6763</citedby><cites>FETCH-LOGICAL-c468t-764285687f14c54ef1bfb5a960123e0ace481dc565bbdf0a6228e6534baac6763</cites><orcidid>0000-0002-1153-2294 ; 0000-0001-9767-2310 ; 0000-0002-2410-9540 ; 0000-0002-9524-3990 ; 0000-0002-1867-0526</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34121594$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chihara, Dai</creatorcontrib><creatorcontrib>Larson, Melissa C.</creatorcontrib><creatorcontrib>Robinson, Dennis P.</creatorcontrib><creatorcontrib>Thompson, Carrie A.</creatorcontrib><creatorcontrib>Maurer, Matthew J.</creatorcontrib><creatorcontrib>Casulo, Carla</creatorcontrib><creatorcontrib>Pophali, Priyanka</creatorcontrib><creatorcontrib>Link, Brian K.</creatorcontrib><creatorcontrib>Habermann, Thomas M.</creatorcontrib><creatorcontrib>Feldman, Andrew L.</creatorcontrib><creatorcontrib>Flowers, Christopher R.</creatorcontrib><creatorcontrib>Cerhan, James R.</creatorcontrib><creatorcontrib>Morton, Lindsay M.</creatorcontrib><title>Body mass index and survival of patients with lymphoma</title><title>Leukemia & lymphoma</title><addtitle>Leuk Lymphoma</addtitle><description>The impact of body mass index (BMI) on survival in lymphoma remains controversial. We leveraged a prospective cohort of lymphoma patients enrolled to SPORE Molecular Epidemiology Resource between 2002 and 2015 to assess the association of BMI before diagnosis, BMI at diagnosis, and BMI change over time with lymphoma-specific survival (LSS). A total of 4009 lymphoma patients (670 diffuse large B-cell lymphoma (DLBCL), 689 follicular lymphoma (FL), 1018 chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), and 1632 other subtypes) were included. Significantly shorter LSS after diagnosis was observed for FL patients who were obese before diagnosis (HR: 3.02, 95%CI: 1.43-6.41, p=.004) and for those with a ≥ 5% increase in BMI from diagnosis to 3-year follow-up (HR: 3.53, 95%CI: 1.22-10.2, p=.020). In contrast, obesity prior to or at the time of diagnosis was not associated with LSS in DLBCL and CLL/SLL. The impact of weight control after diagnosis in FL patient warrants investigation.</description><subject>Body Mass Index</subject><subject>CLL/SLL</subject><subject>Cohort Studies</subject><subject>Diffuse large B-cell lymphoma</subject><subject>follicular lymphoma</subject><subject>Humans</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - epidemiology</subject><subject>Lymphoma, Follicular - diagnosis</subject><subject>Lymphoma, Follicular - epidemiology</subject><subject>Lymphoma, Large B-Cell, Diffuse - diagnosis</subject><subject>Lymphoma, Large B-Cell, Diffuse - epidemiology</subject><subject>Prospective Studies</subject><subject>survival</subject><issn>1042-8194</issn><issn>1029-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kEtPwzAQhC0EolD4CaAcuaTYju0kFwRUvKRKXOBsbRybGiVxsdOW_HsS9SG4cNqVdnZm9CF0QfCE4AxfE8xoRnI2oZiSCclpnnNxgE4IpnlMGU4Oh53ReBCN0GkInxhjngt6jEYJI5TwnJ0gce_KLqohhMg2pf6OoCmjsPQru4IqciZaQGt104Zobdt5VHX1Yu5qOENHBqqgz7dzjN4fH96mz_Hs9ellejeLFRNZG6eiL8lFlhrCFGfakMIUHHKBCU00BqVZRkrFBS-K0mAQlGZa8IQVAEqkIhmjm43vYlnUulR9Ew-VXHhbg--kAyv_Xho7lx9uJbM0JYwmvcHV1sC7r6UOraxtULqqoNFuGSTlDKeUJXTI4hup8i4Er80-hmA5MJc75nJgLrfM-7_L3x33XzvIveB2I7CNcb6GtfNVKVvoKueNh0bZIJP_M34AGTqQ8w</recordid><startdate>20210919</startdate><enddate>20210919</enddate><creator>Chihara, Dai</creator><creator>Larson, Melissa C.</creator><creator>Robinson, Dennis P.</creator><creator>Thompson, Carrie A.</creator><creator>Maurer, Matthew J.</creator><creator>Casulo, Carla</creator><creator>Pophali, Priyanka</creator><creator>Link, Brian K.</creator><creator>Habermann, Thomas M.</creator><creator>Feldman, Andrew L.</creator><creator>Flowers, Christopher R.</creator><creator>Cerhan, James R.</creator><creator>Morton, Lindsay M.</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1153-2294</orcidid><orcidid>https://orcid.org/0000-0001-9767-2310</orcidid><orcidid>https://orcid.org/0000-0002-2410-9540</orcidid><orcidid>https://orcid.org/0000-0002-9524-3990</orcidid><orcidid>https://orcid.org/0000-0002-1867-0526</orcidid></search><sort><creationdate>20210919</creationdate><title>Body mass index and survival of patients with lymphoma</title><author>Chihara, Dai ; Larson, Melissa C. ; Robinson, Dennis P. ; Thompson, Carrie A. ; Maurer, Matthew J. ; Casulo, Carla ; Pophali, Priyanka ; Link, Brian K. ; Habermann, Thomas M. ; Feldman, Andrew L. ; Flowers, Christopher R. ; Cerhan, James R. ; Morton, Lindsay M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-764285687f14c54ef1bfb5a960123e0ace481dc565bbdf0a6228e6534baac6763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Body Mass Index</topic><topic>CLL/SLL</topic><topic>Cohort Studies</topic><topic>Diffuse large B-cell lymphoma</topic><topic>follicular lymphoma</topic><topic>Humans</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - epidemiology</topic><topic>Lymphoma, Follicular - diagnosis</topic><topic>Lymphoma, Follicular - epidemiology</topic><topic>Lymphoma, Large B-Cell, Diffuse - diagnosis</topic><topic>Lymphoma, Large B-Cell, Diffuse - epidemiology</topic><topic>Prospective Studies</topic><topic>survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chihara, Dai</creatorcontrib><creatorcontrib>Larson, Melissa C.</creatorcontrib><creatorcontrib>Robinson, Dennis P.</creatorcontrib><creatorcontrib>Thompson, Carrie A.</creatorcontrib><creatorcontrib>Maurer, Matthew J.</creatorcontrib><creatorcontrib>Casulo, Carla</creatorcontrib><creatorcontrib>Pophali, Priyanka</creatorcontrib><creatorcontrib>Link, Brian K.</creatorcontrib><creatorcontrib>Habermann, Thomas M.</creatorcontrib><creatorcontrib>Feldman, Andrew L.</creatorcontrib><creatorcontrib>Flowers, Christopher R.</creatorcontrib><creatorcontrib>Cerhan, James R.</creatorcontrib><creatorcontrib>Morton, Lindsay M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Leukemia & lymphoma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chihara, Dai</au><au>Larson, Melissa C.</au><au>Robinson, Dennis P.</au><au>Thompson, Carrie A.</au><au>Maurer, Matthew J.</au><au>Casulo, Carla</au><au>Pophali, Priyanka</au><au>Link, Brian K.</au><au>Habermann, Thomas M.</au><au>Feldman, Andrew L.</au><au>Flowers, Christopher R.</au><au>Cerhan, James R.</au><au>Morton, Lindsay M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Body mass index and survival of patients with lymphoma</atitle><jtitle>Leukemia & lymphoma</jtitle><addtitle>Leuk Lymphoma</addtitle><date>2021-09-19</date><risdate>2021</risdate><volume>62</volume><issue>11</issue><spage>2671</spage><epage>2678</epage><pages>2671-2678</pages><issn>1042-8194</issn><eissn>1029-2403</eissn><abstract>The impact of body mass index (BMI) on survival in lymphoma remains controversial. 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| subjects | Body Mass Index CLL/SLL Cohort Studies Diffuse large B-cell lymphoma follicular lymphoma Humans Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis Leukemia, Lymphocytic, Chronic, B-Cell - epidemiology Lymphoma, Follicular - diagnosis Lymphoma, Follicular - epidemiology Lymphoma, Large B-Cell, Diffuse - diagnosis Lymphoma, Large B-Cell, Diffuse - epidemiology Prospective Studies survival |
| title | Body mass index and survival of patients with lymphoma |
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