Folinic Acid Potentiates the Liver Regeneration Process after Selective Portal Vein Ligation in Rats

Liver resection remains the gold standard for hepatic metastases. The future liver remnant (FLR) and its functional status are two key points to consider before performing major liver resections, since patients with less than 25% FLR or a Child-Pugh B or C grade are not eligible for this procedure....

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Published in:Cancers 2022-01, Vol.14 (2), p.371
Main Authors: Gutiérrez Sáenz de Santa María, Jorge, Herrero de la Parte, Borja, Gutiérrez-Sánchez, Gaizka, Ruiz Montesinos, Inmaculada, Iturrizaga Correcher, Sira, Mar Medina, Carmen, García-Alonso, Ignacio
Format: Article
Language:English
Subjects:
Abdomen
Amino acids
Animals
Folinic acid
Hepatectomy
Liver
Metastases
Metastasis
Patients
Portal vein
Surgery
Surgical techniques
Tumors
Veins & arteries
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Summary:Liver resection remains the gold standard for hepatic metastases. The future liver remnant (FLR) and its functional status are two key points to consider before performing major liver resections, since patients with less than 25% FLR or a Child-Pugh B or C grade are not eligible for this procedure. Folinic acid (FA) is an essential agent in cell replication processes. Herein, we analyze the effect of FA as an enhancer of liver regeneration after selective portal vein ligation (PVL). Sixty-four male WAG/RijHsd rats were randomly distributed into eight groups: a control group and seven subjected to 50% PVL, by ligation of left portal branch. The treated animals received FA (2.5 m/kg), while the rest were given saline. After 36 h, 3 days or 7 days, liver tissue and blood samples were obtained. FA slightly but significantly increased FLR percentage (FLR%) on the 7th day (91.88 ± 0.61%) compared to control or saline-treated groups (86.72 ± 2.5 vs. 87 ± 3.33%; < 0.01). The hepatocyte nuclear area was also increased both at 36 h and 7days with FA (61.55 ± 16.09 µm , and 49.91 ± 15.38 µm ; < 0.001). Finally, FA also improved liver function. In conclusion, FA has boosted liver regeneration assessed by FLR%, nuclear area size and restoration of liver function after PVL.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers14020371