Review of the Forensic Applicability of Biostatistical Methods for Inferring Ancestry from Autosomal Genetic Markers

The inference of ancestry has become a part of the services many forensic genetic laboratories provide. Interest in ancestry may be to provide investigative leads or identify the region of origin in cases of unidentified missing persons. There exist many biostatistical methods developed for the stud...

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Bibliographic Details
Published in:Genes 2022-01, Vol.13 (1), p.141
Main Author: Tvedebrink, Torben
Format: Article
Language:English
Subjects:
Discriminant analysis
Ethnicity - genetics
Forensic Genetics - methods
Forensic science
Genetic Markers
Genetics, Population
Genomes
Humans
Hypotheses
Methods
Mitochondrial DNA
Polymorphism, Single Nucleotide
Population genetics
Population structure
Population studies
Principal components analysis
Racial Groups - genetics
Review
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Summary:The inference of ancestry has become a part of the services many forensic genetic laboratories provide. Interest in ancestry may be to provide investigative leads or identify the region of origin in cases of unidentified missing persons. There exist many biostatistical methods developed for the study of population structure in the area of population genetics. However, the challenges and questions are slightly different in the context of forensic genetics, where the origin of a specific sample is of interest compared to the understanding of population histories and genealogies. In this paper, the methodologies for modelling population admixture and inferring ancestral populations are reviewed with a focus on their strengths and weaknesses in relation to ancestry inference in the forensic context.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes13010141