Novel Findings regarding the Bioactivity of the Natural Blue Pigment Genipin in Human Diseases

Genipin is an important monoterpene iridoid compound isolated from J.Ellis fruits and from fruits, or genipap. It is a precursor of a blue pigment which may be attractive alternative to existing food dyes and it possesses various potential therapeutic properties such as anti-cancer, anti-diabetic an...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-01, Vol.23 (2), p.902
Main Authors: Bryś, Magdalena, Urbańska, Karina, Olas, Beata
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Apoptosis
Autophagy
Biocompatibility
Biological activity
Chemical compounds
Color
Diabetes mellitus
Food Additives
Food dyes
Food products
Fruit - chemistry
Fruits
Genipin
Humans
Industrial applications
Insulin
Iridoids - chemistry
Iridoids - pharmacology
Ischemia
Kinases
Lipid peroxidation
Lipids
Neuroprotection
Nitric oxide
Parkinson's disease
Pigments, Biological - chemistry
Plant Extracts - chemistry
Plant Extracts - pharmacology
Protective Agents - chemistry
Protective Agents - pharmacology
Proteins
Review
Toxicity
Tumor necrosis factor-TNF
Ulcers
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Summary:Genipin is an important monoterpene iridoid compound isolated from J.Ellis fruits and from fruits, or genipap. It is a precursor of a blue pigment which may be attractive alternative to existing food dyes and it possesses various potential therapeutic properties such as anti-cancer, anti-diabetic and hepatoprotective activity. Biomedical studies also show that genipin may act as a neuroprotective drug. This review describes new aspects of the bioactivity of genipin against various diseases, as well as its toxicity and industrial applications, and presents its potential mechanism of action.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23020902