Effects of Topical Retinoids on Acne and Post-inflammatory Hyperpigmentation in Patients with Skin of Color: A Clinical Review and Implications for Practice

Acne is a common cause for post-inflammatory hyperpigmentation (PIH), particularly in patients with skin of color (SOC), and PIH is often more distressing to patients than the acne itself. Topical retinoids are approved for the treatment of acne and for pigmentation disorders such as melasma or mott...

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Bibliographic Details
Published in:American journal of clinical dermatology 2022-01, Vol.23 (1), p.69-81
Main Authors: Callender, Valerie D., Baldwin, Hilary, Cook-Bolden, Fran E., Alexis, Andrew F., Stein Gold, Linda, Guenin, Eric
Format: Article
Language:English
Subjects:
Acne
Acne Vulgaris - complications
Acne Vulgaris - drug therapy
Administration, Topical
Black people
Cell growth
Dermatology
Ethnic and Racial Minorities
FDA approval
Gene expression
Hispanic people
Humans
Hyperpigmentation - drug therapy
Hyperpigmentation - etiology
Inflammation
Medicine
Medicine & Public Health
Patient Education as Topic
Pharmacology/Toxicology
Pharmacotherapy
Retinoids - therapeutic use
Skin Care
Skin Pigmentation
Therapy in Practice
Women
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Summary:Acne is a common cause for post-inflammatory hyperpigmentation (PIH), particularly in patients with skin of color (SOC), and PIH is often more distressing to patients than the acne itself. Topical retinoids are approved for the treatment of acne and for pigmentation disorders such as melasma or mottled hyperpigmentation associated with photodamage; moreover, they have been shown to reduce hyperpigmentation in patients with SOC. Therefore, treatment with topical retinoids should be started as early as possible unless contraindicated. Use of novel formulations or application of commonly recommended moisturizers may help reduce irritation. Combining retinoids with other topical agents and procedures such as superficial chemical peels can help to improve hyperpigmentation. Primary acne lesions are likely to improve weeks before PIH resolves and helping patients manage their expectations may reduce frustration. Providing clinicians and researchers with more education about the presentation and management of dermatologic conditions in patients with SOC is also recommended.
ISSN:1175-0561
1179-1888
1179-1888
DOI:10.1007/s40257-021-00643-2