Involvement of transcribed lncRNA uc.291 and SWI/SNF complex in cutaneous squamous cell carcinoma

While non-melanoma skin cancers (NMSCs) are the most common tumours in humans, only the sub-type cutaneous squamous cell carcinoma (cSCC), might become metastatic with high lethality. We have recently identified a regulatory pathway involving the lncRNA transcript uc.291 in controlling the expressio...

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Bibliographic Details
Published in:Discover. Oncology 2021-05, Vol.12 (1), p.14-14, Article 14
Main Authors: Mancini, M., Cappello, A., Pecorari, R., Lena, A. M., Montanaro, M., Fania, L., Ricci, F., Di Lella, G., Piro, M. C., Abeni, D., Dellambra, E., Mauriello, A., Melino, G., Candi, E.
Format: Article
Language:English
Subjects:
Cancer Research
Epigenetics
Hirsch index
Internal Medicine
Medicine
Medicine & Public Health
Melanoma
Molecular Medicine
Mutation
Oncology
Pathogenesis
Radiotherapy
Skin cancer
Squamous cell carcinoma
Surgical Oncology
Tumors
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Summary:While non-melanoma skin cancers (NMSCs) are the most common tumours in humans, only the sub-type cutaneous squamous cell carcinoma (cSCC), might become metastatic with high lethality. We have recently identified a regulatory pathway involving the lncRNA transcript uc.291 in controlling the expression of epidermal differentiation complex genes via the interaction with ACTL6A, a component of the chromatin remodelling complex SWI/SNF. Since transcribed ultra-conserved regions (T-UCRs) are expressed in normal tissues and are deregulated in tumorigenesis, here we hypothesize a potential role for dysregulation of this axis in cSCC, accounting for the de-differentiation process observed in aggressive poorly differentiated cutaneous carcinomas. We therefore analysed their expression patterns in human tumour biopsies at mRNA and protein levels. The results suggest that by altering chromatin accessibility of the epidermal differentiation complex genes, down-regulation of uc.291 and BRG1 expression contribute to the de-differentiation process seen in keratinocyte malignancy. This provides future direction for the identification of clinical biomarkers in cutaneous SCC. Analysis of publicly available data sets indicates that the above may also be a general feature for SCCs of different origins.
ISSN:2730-6011
2730-6011
DOI:10.1007/s12672-021-00409-6