Association between kidney function and incidence of dementia: 10-year follow-up of the Whitehall II cohort study

Abstract Background Cognitive dysfunction is common in haemodialysis patients but whether poor kidney function in the general population is also associated with higher risk of dementia remains unclear. Objective To examine the association of kidney function with incident dementia in community dwelli...

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Bibliographic Details
Published in:Age and ageing 2022-01, Vol.51 (1)
Main Authors: Singh-Manoux, Archana, Oumarou-Ibrahim, Amina, Machado-Fragua, Marcos D, Dumurgier, Julien, Brunner, Erics J, Kivimaki, Mika, Fayosse, Aurore, Sabia, Sèverine
Format: Article
Language:English
Subjects:
Aged
Cardiovascular diseases
Cognitive ability
Cohort analysis
Cohort Studies
Community living
Computerized medical records
Dementia
Dementia - diagnosis
Dementia - epidemiology
Dementia disorders
Diabetes
Diabetes mellitus
Dialysis
Drugs
Electronic medical records
Epidermal growth factor receptors
Follow-Up Studies
Glomerular Filtration Rate
Health records
Hemodialysis
Humans
Hypertension
Incidence
Kidney
Kidneys
Life Sciences
Neurons and Cognition
Obesity
Older people
Population studies
Prospective Studies
Renal Insufficiency, Chronic - diagnosis
Renal Insufficiency, Chronic - epidemiology
Research Paper
Risk Factors
Sociodemographic Factors
Sociodemographics
Stroke
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Summary:Abstract Background Cognitive dysfunction is common in haemodialysis patients but whether poor kidney function in the general population is also associated with higher risk of dementia remains unclear. Objective To examine the association of kidney function with incident dementia in community dwelling older adults. Design Whitehall II prospective study. Setting Population-based study on 6,050 adults, mean age 65.8 in 2007–2009. Methods Poor kidney function, defined as estimated Glomerular Filtration Rate (eGFR)
ISSN:0002-0729
1468-2834
DOI:10.1093/ageing/afab259