Invasive fungal sinusitis and meningitis due to Arthrographis kalrae in a patient with AIDS

We report the first described case of Arthrographis kalrae pansinusitis and meningitis in a patient with AIDS. The patient was initially diagnosed with Arthrographis kalrae pansinusitis by endoscopic biopsy and culture. The patient was treated with itraconazole for approximately 5 months and then di...

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Bibliographic Details
Published in:Journal of clinical microbiology 2001-02, Vol.39 (2), p.804-807
Main Authors: CHIN-HONG, Peter V, SUTTON, Deanna A, ROEMER, Marguerite, JACOBSON, Mark A, ABERG, Judith A
Format: Article
Language:English
Subjects:
Adult
AIDS-Related Opportunistic Infections - complications
AIDS-Related Opportunistic Infections - microbiology
Arthrographis kalrae
Biological and medical sciences
Case Reports
Fatal Outcome
Human immunodeficiency virus
Human mycoses
Humans
Infectious diseases
Male
Medical sciences
Meningitis, Fungal - microbiology
Meningitis, Fungal - pathology
Mitosporic Fungi - classification
Mitosporic Fungi - isolation & purification
Mycoses
Mycoses - complications
Mycoses - pathology
Mycoses of the nervous system
Pneumocystis carinii
Pneumonia, Pneumocystis - complications
Pneumonia, Pneumocystis - pathology
Sphenoid Sinusitis - microbiology
Sphenoid Sinusitis - pathology
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Summary:We report the first described case of Arthrographis kalrae pansinusitis and meningitis in a patient with AIDS. The patient was initially diagnosed with Arthrographis kalrae pansinusitis by endoscopic biopsy and culture. The patient was treated with itraconazole for approximately 5 months and then died secondary to Pneumocytis carinii pneumonia. Postmortem examination revealed invasive fungal sinusitis that involved the sphenoid sinus and that extended through the cribiform plate into the inferior surfaces of the bilateral frontal lobes. There was also an associated fungal meningitis and vasculitis with fungal thrombosis and multiple recent infarcts that involved the frontal lobes, right caudate nucleus, and putamen. Post mortem cultures were positive for A. kalrae.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.39.2.804-807.2001