Focal Segmental Glomerulosclerosis, Risk Factors for End Stage Kidney Disease, and Response to Immunosuppression

FSGS is a heterogeneic glomerular disease. Risk factors for kidney disease ESKD and the effect of immunosuppression treatment (IST) has varied in previously published cohorts. These cohorts were limited by relatively small case numbers, short follow-up, lack of racial/ethnic diversity, a mix of adul...

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Bibliographic Details
Published in:Kidney360 2021-01, Vol.2 (1), p.105-113
Main Authors: Forster, Benjamin M, Nee, Robert, Little, Dustin J, Greasley, Peter J, Hughes, James B, Gordon, Sarah M, Olson, Stephen W
Format: Article
Language:English
Subjects:
Adult
Child
Glomerulosclerosis, Focal Segmental - drug therapy
Humans
Immunosuppression Therapy - adverse effects
Kidney - pathology
Kidney Failure, Chronic - epidemiology
Original Investigations
Risk Factors
United States
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Summary:FSGS is a heterogeneic glomerular disease. Risk factors for kidney disease ESKD and the effect of immunosuppression treatment (IST) has varied in previously published cohorts. These cohorts were limited by relatively small case numbers, short follow-up, lack of racial/ethnic diversity, a mix of adult and pediatric patients, lack of renin-angiotensin-aldosterone system (RAAS) inhibition, or lack of subgroup analysis of IST. We compared demographics, clinical characteristics, histopathology, and IST to long-term renal survival in a large, ethnically diverse, adult cohort of 338 patients with biopsy-proven FSGS with long-term follow-up in the era of RAAS inhibition using data from the US Department of Defense health care network. Multivariate analysis showed that nephrotic-range proteinuria (NRP), eGFR
ISSN:2641-7650
2641-7650
DOI:10.34067/KID.0006172020