Osmotic Demyelination Syndrome following Correction of Hyponatremia by ≤10 mEq/L per Day

Overly rapid correction of chronic hyponatremia may lead to osmotic demyelination syndrome. European guidelines recommend a correction to ≤10 mEq/L in 24 hours to prevent this complication. However, osmotic demyelination syndrome may occur despite adherence to these guidelines. We searched the liter...

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Bibliographic Details
Published in:Kidney360 2021-09, Vol.2 (9), p.1415-1423
Main Authors: Tandukar, Srijan, Sterns, Richard H, Rondon-Berrios, Helbert
Format: Article
Language:English
Subjects:
Demyelinating Diseases - complications
Humans
Hyponatremia - etiology
Male
Middle Aged
Original Investigation
Osmosis
Sodium
Syndrome
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Summary:Overly rapid correction of chronic hyponatremia may lead to osmotic demyelination syndrome. European guidelines recommend a correction to ≤10 mEq/L in 24 hours to prevent this complication. However, osmotic demyelination syndrome may occur despite adherence to these guidelines. We searched the literature for reports of osmotic demyelination syndrome with rates of correction of hyponatremia ≤10 mEq/L in 24 hours. The reports were reviewed to identify specific risk factors for this complication. We identified 19 publications with a total of 21 patients that were included in our analysis. The mean age was 52 years, of which 67% were male. All of the patients had community-acquired chronic hyponatremia. Twelve patients had an initial serum sodium
ISSN:2641-7650
2641-7650
DOI:10.34067/KID.0004402021