Fibroblast heterogeneity in prostate carcinogenesis

Our understanding of stromal components, specifically cancer-associated fibroblasts (CAF), in prostate cancer (PCa), has evolved from considering these cells as inert bystanders to acknowledging their significance as players in prostate tumorigenesis. CAF are multifaceted-they promote cancer cell gr...

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Bibliographic Details
Published in:Cancer letters 2022-01, Vol.525, p.76-83
Main Authors: ChallaSivaKanaka, Sathyavathi, Vickman, Renee E., Kakarla, Mamatha, Hayward, Simon W., Franco, Omar E.
Format: Article
Language:English
Subjects:
Androgens
Apoptosis
Bone marrow
Cancer associated fibroblasts
Cancer therapies
Cancer-Associated Fibroblasts - metabolism
Cancer-Associated Fibroblasts - pathology
Carcinogenesis
Carcinogenesis - genetics
Cell Lineage - genetics
Cell migration
Epithelium
Epithelium - metabolism
Epithelium - pathology
Fibroblast heterogeneity
Fibroblasts
Genetic Heterogeneity
Growth factors
Homeostasis
Humans
Male
Myofibroblasts
Prostate cancer
Prostatic Neoplasms - genetics
Prostatic Neoplasms - pathology
Proteins
Smooth muscle
Stem cells
Stromal Cells - metabolism
Stromal Cells - pathology
Stromal heterogeneity
Tumor microenvironment
Tumor Microenvironment - genetics
Tumorigenesis
Tumors
Wound healing
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Summary:Our understanding of stromal components, specifically cancer-associated fibroblasts (CAF), in prostate cancer (PCa), has evolved from considering these cells as inert bystanders to acknowledging their significance as players in prostate tumorigenesis. CAF are multifaceted-they promote cancer cell growth, migration and remodel the tumor microenvironment. Although targeting CAF could be a promising strategy for PCa treatment, they incorporate a high but undefined degree of intrinsic cellular heterogeneity. The interaction between CAF subpopulations, with the normal and tumor epithelium and with other cell types is not yet characterized. Defining these interactions and the critical signaling nodes that support tumorigenesis will enable the development of novel strategies to control prostate cancer progression. Here we will discuss the origins, molecular and functional heterogeneity of CAF in PCa. We highlight the challenges associated with delineating CAF heterogeneity and discuss potential areas of research that would assist in expanding our knowledge of CAF and their role in PCa tumorigenesis. •Prostate cancer stroma contains diverse populations of fibroblasts.•Carcinoma associated fibroblasts can promote prostate carcinogenesis.•Interaction among fibroblast subsets modulate stromal-epithelial paracrine signaling.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2021.10.028