Bariatric Surgery Leads to a Reduction in Antibodies to Apolipoprotein A-1: a Prospective Cohort Study

Purpose Autoantibodies against apolipoprotein A-1 have been associated with cardiovascular disease, poorer CV outcomes and all-cause mortality in obese individuals. The impact of bariatric surgery (BS) on the presence of circulating anti-apoA-1 IgG antibodies is unknown. This study aimed to determin...

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Bibliographic Details
Published in:Obesity surgery 2022-02, Vol.32 (2), p.355-364
Main Authors: Adam, Safwaan, Ho, Jan H., Liu, Yifen, Siahmansur, Tarza, Iqbal, Zohaib, Pagano, Sabrina, Azmi, Shazli, Dhage, Shaishav S., Donn, Rachelle, Ammori, Basil J., Syed, Akheel A., Durrington, Paul N., Malik, Rayaz A., Vuilleumier, Nicolas, Soran, Handrean
Format: Article
Language:English
Subjects:
Antibodies
Apolipoproteins
Body mass index
Cohort analysis
Gastrointestinal surgery
High density lipoprotein
Insulin resistance
Medicine
Medicine & Public Health
Original Contributions
Surgery
Triglycerides
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Summary:Purpose Autoantibodies against apolipoprotein A-1 have been associated with cardiovascular disease, poorer CV outcomes and all-cause mortality in obese individuals. The impact of bariatric surgery (BS) on the presence of circulating anti-apoA-1 IgG antibodies is unknown. This study aimed to determine the effect of bariatric surgery on auto-antibodies titres against Apolipoprotein A-1 (anti-apoA-1 IgG), looking for changes associated with lipid parameters, insulin resistance, inflammatory profile and percentage of excess body mass index loss (%EBMIL). Materials and Methods We assessed 55 patients (40 women) before, 6 and 12 months post-operatively. Baseline and post-operative clinical history and measurements of body mass index (BMI), serum cholesterol, triglycerides, high- and low-density lipoprotein cholesterol (HDL-C and LDL-C), apoA-1, highly sensitive C-reactive protein (hsCRP), fasting glucose (FG), glycated haemoglobin (HbA1c) and HOMA-IR were taken at each point. Human anti-apoA-1 IgG were measured by ELISA. Results The mean age of participants was 50 years. BS significantly improved BMI, %EBMIL triglycerides, HDL-C, apoA-1, hsCRP, HBA1c, FG and HOMA-IR. Baseline anti-apoA-1 IgG seropositivity was 25% and was associated with lower apoA-1 and higher hsCRP levels. One year after BS, anti-apoA-1 IgG seropositivity decreased to 15% ( p  = 0.007) and median anti-apoA-1 IgG values decreased from 0.70 (0.56–0.84) to 0.47 (0.37–0.61) AU ( p  
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-021-05738-7