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Microtubule-associated protein tau in murine kidney: role in podocyte architecture
Tau is a cytoskeletal protein that is expressed mainly in neurons and is involved in several cellular processes, such as microtubule stabilization, axonal maintenance, and transport. Altered tau metabolism is related to different tauopathies being the most important Alzheimer’s disease where aberran...
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| Published in: | Cellular and molecular life sciences : CMLS 2022-02, Vol.79 (2), p.97-97, Article 97 |
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| container_end_page | 97 |
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| container_title | Cellular and molecular life sciences : CMLS |
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| creator | Vallés-Saiz, Laura Peinado-Cahuchola, Rocio Ávila, Jesús Hernández, Félix |
| description | Tau is a cytoskeletal protein that is expressed mainly in neurons and is involved in several cellular processes, such as microtubule stabilization, axonal maintenance, and transport. Altered tau metabolism is related to different tauopathies being the most important Alzheimer’s disease where aberrant hyperphosphorylated and aggregated tau is found in the central nervous system. Here, we have analyzed that function in kidney by using tau knockout mice generated by integrating GFP-encoding cDNA into exon 1 of
MAPT
(here referred to as Tau
GFP/GFP
). IVIS Lumina from PerkinElmer demonstrated GFP expression in the kidney. We then demonstrated by qPCR that the main tau isoform in the kidney is Tau4R. The GFP reporter allowed us to demonstrate that tau is found in the glomeruli of the renal cortex, and specifically in podocytes. This was further confirmed by immunohistochemistry. Tau
G
FP/GFP
mice present a podocyte cytoskeleton more dynamic as they contain higher levels of detyrosinated tubulin than wild-type mice. In addition, transmission electron microscopy studies demonstrated glomerular damage with a decrease in urinary creatinine. Our results prove that tau has an important role in kidney metabolism under normal physiological conditions. |
| doi_str_mv | 10.1007/s00018-021-04106-z |
| format | article |
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MAPT
(here referred to as Tau
GFP/GFP
). IVIS Lumina from PerkinElmer demonstrated GFP expression in the kidney. We then demonstrated by qPCR that the main tau isoform in the kidney is Tau4R. The GFP reporter allowed us to demonstrate that tau is found in the glomeruli of the renal cortex, and specifically in podocytes. This was further confirmed by immunohistochemistry. Tau
G
FP/GFP
mice present a podocyte cytoskeleton more dynamic as they contain higher levels of detyrosinated tubulin than wild-type mice. In addition, transmission electron microscopy studies demonstrated glomerular damage with a decrease in urinary creatinine. Our results prove that tau has an important role in kidney metabolism under normal physiological conditions.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-021-04106-z</identifier><identifier>PMID: 35084555</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Alzheimer's disease ; Animals ; Axonal transport ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Central nervous system ; Creatinine ; Cytoskeleton ; Cytoskeleton - metabolism ; Green Fluorescent Proteins - genetics ; Green Fluorescent Proteins - metabolism ; Immunohistochemistry ; Kidney - cytology ; Kidney - metabolism ; Kidney - ultrastructure ; Kidney Glomerulus - metabolism ; Kidney Glomerulus - ultrastructure ; Kidneys ; Life Sciences ; Metabolism ; Mice ; Mice, 129 Strain ; Mice, Knockout ; Mice, Transgenic ; Microscopy, Confocal ; Microscopy, Immunoelectron ; Microtubules - metabolism ; Neurodegenerative diseases ; Original ; Original Article ; Podocytes - metabolism ; Proteins ; Renal cortex ; Tau protein ; tau Proteins - genetics ; tau Proteins - metabolism ; Tauopathies - genetics ; Tauopathies - metabolism ; Transmission electron microscopy ; Tubulin</subject><ispartof>Cellular and molecular life sciences : CMLS, 2022-02, Vol.79 (2), p.97-97, Article 97</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-57fb91e9da6f25c1a23c641193aaf588036c6febe3b6b9034baf4e1cdd99db143</citedby><cites>FETCH-LOGICAL-c474t-57fb91e9da6f25c1a23c641193aaf588036c6febe3b6b9034baf4e1cdd99db143</cites><orcidid>0000-0001-8753-8249</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794918/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8794918/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35084555$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vallés-Saiz, Laura</creatorcontrib><creatorcontrib>Peinado-Cahuchola, Rocio</creatorcontrib><creatorcontrib>Ávila, Jesús</creatorcontrib><creatorcontrib>Hernández, Félix</creatorcontrib><title>Microtubule-associated protein tau in murine kidney: role in podocyte architecture</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>Tau is a cytoskeletal protein that is expressed mainly in neurons and is involved in several cellular processes, such as microtubule stabilization, axonal maintenance, and transport. Altered tau metabolism is related to different tauopathies being the most important Alzheimer’s disease where aberrant hyperphosphorylated and aggregated tau is found in the central nervous system. Here, we have analyzed that function in kidney by using tau knockout mice generated by integrating GFP-encoding cDNA into exon 1 of
MAPT
(here referred to as Tau
GFP/GFP
). IVIS Lumina from PerkinElmer demonstrated GFP expression in the kidney. We then demonstrated by qPCR that the main tau isoform in the kidney is Tau4R. The GFP reporter allowed us to demonstrate that tau is found in the glomeruli of the renal cortex, and specifically in podocytes. This was further confirmed by immunohistochemistry. Tau
G
FP/GFP
mice present a podocyte cytoskeleton more dynamic as they contain higher levels of detyrosinated tubulin than wild-type mice. In addition, transmission electron microscopy studies demonstrated glomerular damage with a decrease in urinary creatinine. Our results prove that tau has an important role in kidney metabolism under normal physiological conditions.</description><subject>Alzheimer's disease</subject><subject>Animals</subject><subject>Axonal transport</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Central nervous system</subject><subject>Creatinine</subject><subject>Cytoskeleton</subject><subject>Cytoskeleton - metabolism</subject><subject>Green Fluorescent Proteins - genetics</subject><subject>Green Fluorescent Proteins - metabolism</subject><subject>Immunohistochemistry</subject><subject>Kidney - cytology</subject><subject>Kidney - metabolism</subject><subject>Kidney - ultrastructure</subject><subject>Kidney Glomerulus - metabolism</subject><subject>Kidney Glomerulus - ultrastructure</subject><subject>Kidneys</subject><subject>Life Sciences</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Mice, 129 Strain</subject><subject>Mice, Knockout</subject><subject>Mice, Transgenic</subject><subject>Microscopy, Confocal</subject><subject>Microscopy, Immunoelectron</subject><subject>Microtubules - metabolism</subject><subject>Neurodegenerative diseases</subject><subject>Original</subject><subject>Original Article</subject><subject>Podocytes - metabolism</subject><subject>Proteins</subject><subject>Renal cortex</subject><subject>Tau protein</subject><subject>tau Proteins - genetics</subject><subject>tau Proteins - metabolism</subject><subject>Tauopathies - genetics</subject><subject>Tauopathies - metabolism</subject><subject>Transmission electron microscopy</subject><subject>Tubulin</subject><issn>1420-682X</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kV1rFTEQhoMo9kP_gBey4I03azP52o0XQilWhUpBFLwL2exsm7pnc8yHcPrrTXuOrXrRqxlmnnmTmZeQF0DfAKXdUaKUQt9SBi0VQFV7_Yjsg2C01bSDx7tc9ez7HjlI6arSsmfqKdnjkvZCSrlPvnz2LoZchjJja1MKztuMY7OuRfRLk21paliV6Bdsfvhxwc3bJoYZb8rrMAa3ydjY6C59RpdLxGfkyWTnhM938ZB8O33_9eRje3b-4dPJ8VnrRCdyK7tp0IB6tGpi0oFl3CkBoLm1k-x7ypVTEw7IBzVoysVgJ4HgxlHrcQDBD8m7re66DCscHS452tmso1_ZuDHBevNvZ_GX5iL8Mn2nhYa-CrzeCcTws2DKZuWTw3m2C4aSDFOMc6Zlpyr66j_0KpS41PVuKdCdBloptqXqSVOKON19Bqi5scxsLTPVMnNrmbmuQy__XuNu5I9HFeBbINXWcoHx_u0HZH8DhmGkZQ</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Vallés-Saiz, Laura</creator><creator>Peinado-Cahuchola, Rocio</creator><creator>Ávila, Jesús</creator><creator>Hernández, Félix</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8753-8249</orcidid></search><sort><creationdate>20220201</creationdate><title>Microtubule-associated protein tau in murine kidney: role in podocyte architecture</title><author>Vallés-Saiz, Laura ; Peinado-Cahuchola, Rocio ; Ávila, Jesús ; Hernández, Félix</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-57fb91e9da6f25c1a23c641193aaf588036c6febe3b6b9034baf4e1cdd99db143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alzheimer's disease</topic><topic>Animals</topic><topic>Axonal transport</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Central nervous system</topic><topic>Creatinine</topic><topic>Cytoskeleton</topic><topic>Cytoskeleton - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular and molecular life sciences : CMLS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vallés-Saiz, Laura</au><au>Peinado-Cahuchola, Rocio</au><au>Ávila, Jesús</au><au>Hernández, Félix</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microtubule-associated protein tau in murine kidney: role in podocyte architecture</atitle><jtitle>Cellular and molecular life sciences : CMLS</jtitle><stitle>Cell. Mol. Life Sci</stitle><addtitle>Cell Mol Life Sci</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>79</volume><issue>2</issue><spage>97</spage><epage>97</epage><pages>97-97</pages><artnum>97</artnum><issn>1420-682X</issn><eissn>1420-9071</eissn><abstract>Tau is a cytoskeletal protein that is expressed mainly in neurons and is involved in several cellular processes, such as microtubule stabilization, axonal maintenance, and transport. Altered tau metabolism is related to different tauopathies being the most important Alzheimer’s disease where aberrant hyperphosphorylated and aggregated tau is found in the central nervous system. Here, we have analyzed that function in kidney by using tau knockout mice generated by integrating GFP-encoding cDNA into exon 1 of
MAPT
(here referred to as Tau
GFP/GFP
). IVIS Lumina from PerkinElmer demonstrated GFP expression in the kidney. We then demonstrated by qPCR that the main tau isoform in the kidney is Tau4R. The GFP reporter allowed us to demonstrate that tau is found in the glomeruli of the renal cortex, and specifically in podocytes. This was further confirmed by immunohistochemistry. Tau
G
FP/GFP
mice present a podocyte cytoskeleton more dynamic as they contain higher levels of detyrosinated tubulin than wild-type mice. In addition, transmission electron microscopy studies demonstrated glomerular damage with a decrease in urinary creatinine. Our results prove that tau has an important role in kidney metabolism under normal physiological conditions.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>35084555</pmid><doi>10.1007/s00018-021-04106-z</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-8753-8249</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Cellular and molecular life sciences : CMLS, 2022-02, Vol.79 (2), p.97-97, Article 97 |
| issn | 1420-682X 1420-9071 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8794918 |
| source | Springer Nature:Jisc Collections:Springer Nature Read and Publish 2023-2025: Springer Reading List; PubMed Central |
| subjects | Alzheimer's disease Animals Axonal transport Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Central nervous system Creatinine Cytoskeleton Cytoskeleton - metabolism Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Immunohistochemistry Kidney - cytology Kidney - metabolism Kidney - ultrastructure Kidney Glomerulus - metabolism Kidney Glomerulus - ultrastructure Kidneys Life Sciences Metabolism Mice Mice, 129 Strain Mice, Knockout Mice, Transgenic Microscopy, Confocal Microscopy, Immunoelectron Microtubules - metabolism Neurodegenerative diseases Original Original Article Podocytes - metabolism Proteins Renal cortex Tau protein tau Proteins - genetics tau Proteins - metabolism Tauopathies - genetics Tauopathies - metabolism Transmission electron microscopy Tubulin |
| title | Microtubule-associated protein tau in murine kidney: role in podocyte architecture |
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