Heart Rate and Outcomes in Hospitalized Patients With Heart Failure With Preserved Ejection Fraction

A lower heart rate is associated with better outcomes in patients with heart failure (HF) with reduced ejection fraction (EF). Less is known about this association in patients with HF with preserved ejection fraction (HFpEF). The aims of this study were to examine associations of discharge heart rat...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2017-10, Vol.70 (15), p.1861-1871
Main Authors: Lam, Phillip H., Dooley, Daniel J., Deedwania, Prakash, Singh, Steven N., Bhatt, Deepak L., Morgan, Charity J., Butler, Javed, Mohammed, Selma F., Wu, Wen-Chih, Panjrath, Gurusher, Zile, Michael R., White, Michel, Arundel, Cherinne, Love, Thomas E., Blackman, Marc R., Allman, Richard M., Aronow, Wilbert S., Anker, Stefan D., Fonarow, Gregg C., Ahmed, Ali
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - therapeutic use
Aged
Aged, 80 and over
all-cause mortality
all-cause readmission
atrial fibrillation
Beta blockers
Cardiac arrhythmia
Cardiology
Confidence intervals
Female
Follow-Up Studies
Government programs
Health care
Heart diseases
Heart failure
Heart Failure - diagnosis
Heart Failure - mortality
Heart Failure - physiopathology
Heart Failure - therapy
Heart Rate
Hospitalization - statistics & numerical data
Humans
Male
Medicare
Medicare - statistics & numerical data
Mortality
Outcome and Process Assessment, Health Care
Patient Acuity
Patient Discharge - statistics & numerical data
Patient Readmission - statistics & numerical data
Patients
propensity score
Proportional Hazards Models
Registries
Risk Assessment
Stroke Volume
Survival analysis
United States - epidemiology
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Summary:A lower heart rate is associated with better outcomes in patients with heart failure (HF) with reduced ejection fraction (EF). Less is known about this association in patients with HF with preserved ejection fraction (HFpEF). The aims of this study were to examine associations of discharge heart rate with outcomes in hospitalized patients with HFpEF. Of the 8,873 hospitalized patients with HFpEF (EF ≥50%) in the Medicare-linked OPTIMIZE-HF (Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure) registry, 6,286 had a stable heart rate, defined as ≤20 beats/min variation between admission and discharge. Of these, 2,369 (38%) had a discharge heart rate of 
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2017.08.022