Maternal trajectories of cannabis use and young adult cannabis and nicotine dependence

• Published in: Addictive behaviors 2022-03, Vol.126, p.107212-107212, Article 107212
• Main Authors: De Genna, Natacha M., Goldschmidt, Lidush, Richardson, Gale A., Day, Nancy L.
• Format: Article
• Language: English
• Subjects: Adult; Cannabis; Dependence; Female; Hallucinogens; Humans; Inter-generational; Maternal; Mothers; Pregnancy; Tobacco; Tobacco Use; Tobacco Use Disorder - epidemiology; Trajectories; Young Adult
• ISSN: 0306-4603; 1873-6327
• DOI: 10.1016/j.addbeh.2021.107212

[Display omitted] •Cannabis use during and after pregnancy is increasing among women.•Patterns of maternal cannabis use predicts cannabis use in offspring.•Adult cannabis use and CUD is predicted by chronic maternal cannabis use.•Chronic maternal cannabis use also predicts nicotine dependence in offspring. The goals of this study were to model maternal patterns of cannabis use from one year pre-pregnancy to 16 years postpartum and to determine if different patterns of maternal cannabis use predicted offspring substance use at age 22. Women were recruited from a prenatal clinic between 1982 and 1984. Maternal cannabis use was assessed by trained interviewers twice during pregnancy, at delivery, 8 and 18 months, 3, 6, 10, 14, and 16 years postpartum. At age 22, substance use and dependence were measured in offspring. Growth mixture models of maternal cannabis use were calculated and adult offspring substance use outcomes were regressed onto maternal cannabis trajectory classes (n = 551). There were five distinct patterns of maternal cannabis use. Offspring of mothers who were chronic cannabis users were more likely to use cannabis (p