The Death Receptor Pathway of Apoptosis

Green considers a pathway of apoptosis, the mitochondrial pathway, which is activated in response to cellular stress and some developmental cues. He discusses a different pathway of apoptosis that is triggered by the interaction of extracellular ligands with receptors on the cell surface. On the sur...

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Bibliographic Details
Published in:Cold Spring Harbor perspectives in biology 2022-02, Vol.14 (2), p.a041053
Main Author: Green, Douglas R
Format: Article
Language:English
Subjects:
Apoptosis
Caspase
Cell surface
Cellular stress response
Death
Death receptors
fas Receptor - metabolism
Ligands
Mammalian cells
Mitochondria
Mortality
PRIMER
Receptors
Receptors, Death Domain - metabolism
Vertebrates
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Summary:Green considers a pathway of apoptosis, the mitochondrial pathway, which is activated in response to cellular stress and some developmental cues. He discusses a different pathway of apoptosis that is triggered by the interaction of extracellular ligands with receptors on the cell surface. On the surfaces of some mammalian cells (and probably those of other vertebrates as well) are receptors that, when bound by their ligands, engage a pathway of caspase activation and apoptosis that can be distinct from the mitochondrial pathway that we have discussed. These surface molecules are referred to as "death receptors," and their mode of caspase activation is called the death receptor pathway of apoptosis.
ISSN:1943-0264
1943-0264
DOI:10.1101/cshperspect.a041053