Pulse transit time as a diagnostic test for OSA in children with Down syndrome

• Published in: Journal of clinical sleep medicine 2022-01, Vol.18 (1), p.119-128
• Main Authors: Ioan, Iulia, Weick, Diane, Sevin, François, Sanlaville, Damien, De Fréminville, Bénédicte, Schweitzer, Cyril, Akkari, Mohamed, Coutier, Laurianne, Putois, Benjamin, Thieux, Marine, Franco, Patricia
• Format: Article
• Language: English
• Subjects: Child; Diagnostic Tests, Routine; Down Syndrome; Down Syndrome - complications; Down Syndrome - diagnosis; Humans; Life Sciences; Neurons and Cognition; Prospective Studies; Pulse Wave Analysis; Scientific Investigations; Sleep Apnea, Obstructive; Sleep Apnea, Obstructive - diagnosis
• ISSN: 1550-9389; 1550-9397
• DOI: 10.5664/jcsm.9510

Children with Down syndrome (DS) are at risk of obstructive sleep apnea (OSA), but the access to sleep lab polysomnography (PSG) is limited. Simplified techniques are needed, such as polygraphy coupled with pulse transit time (PTT-PG) that detects respiratory events and the total autonomic arousals index (PTTAI). Our objective was to assess the ability of PTT-PG compared with PSG to diagnose OSA in children with DS. In this prospective multicenter study, patients with DS underwent a full-night PSG coupled with PTT. Sleep questionnaires (Sleep Disturbance Scale for Children and Pediatric Sleep Questionnaire) were filled by parents. PSG and PTT-PG results were compared to test their sensibility and specificity to diagnose OSA. A total of 53 patients with DS were included; their median age was 9.3 years. An obstructive apnea-hypopnea index (OAHI) by PSG > 1 event/h was found in 36 (68%) patients, OAHI was > 1 and < 5 events/h in 18 patients (34%), ≥ 5 and < 10 events/h in 11 patients (21%), and ≥ 10 events/h in 7 patients (13%). OAHI was larger on PSG than on PTT-PG ( = .0005). For OSA diagnosis, the sensitivity was excellent for OAHI by PTT-PG if the added total PTTAI was > 1 event/h (1.0) and the specificity was high for the Pediatric Sleep Questionnaire (0.88) and OAHI > 1 event/h on PTT-PG (1.0). More than two-thirds of children with DS referred for screening by a genetics specialist had OSA diagnosed by PSG. With its excellent sensitivity and specificity, PTT-PG could be a good and simplified alternative to PSG to diagnose OSA in children with DS. Ioan I, Weick D, Sevin F, et al. Pulse transit time as a diagnostic test for OSA in children with Down syndrome. . 2022;18(1):119-128.