Visual and histological evaluation of the effects of trafermin in a dog oronasal fistula model

The standard procedure to treat oronasal fistula in dogs requires tooth extraction to close the fistula; hence, the subject would lose its tooth. In this study, trafermin was applied to four dog models with oronasal fistula to investigate the periodontal tissue regenerative effects of trafermin in t...

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Bibliographic Details
Published in:Journal of Veterinary Medical Science 2022, Vol.84(1), pp.64-68
Main Authors: WATANABE, Kazuhiro, TAHARA, Syun, KOYAMA, Hiroyuki, SHIMIZU, Mamu, KAWABE, Mifumi, MIYAWAKI, Shingo
Format: Article
Language:English
Subjects:
Animals
Canine teeth
dog
Dog Diseases
Dogs
Fibroblast Growth Factors
Fistula
Fistula - veterinary
Fistulae
Nose Diseases - veterinary
Oral Fistula - veterinary
oronasal fistula
Peptide Fragments
periodontal regeneration
recombinant human basic fibroblast growth factor
Surgery
trafermin
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Description
Summary:The standard procedure to treat oronasal fistula in dogs requires tooth extraction to close the fistula; hence, the subject would lose its tooth. In this study, trafermin was applied to four dog models with oronasal fistula to investigate the periodontal tissue regenerative effects of trafermin in the treatment without tooth extraction. A fistula was created along the palatal side of each upper canine tooth. One of the fistulae was filled with trafermin, whereas that on the contralateral side was left unfilled as a control. The results showed a significant decrease in the non-calcified periodontal tissue volume on the trafermin side after the fourth week. In addition, oronasal fistula closure was visually and histologically confirmed at the eighth week on the trafermin side of all four models.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.21-0393