Utility of severity assessment tools in COVID-19 pneumonia: a multicentre observational study

Severity scores in pneumonia and sepsis are being applied to SARS-CoV-2 infection. We aimed to assess whether these severity scores are accurate predictors of early adverse outcomes in COVID-19. We conducted a multicentre observational study of hospitalised SARS-CoV-2 infection. We assessed risk sco...

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Published in:Clinical medicine (London, England) England), 2022-01, Vol.22 (1), p.63-70
Main Authors: Ahmed, Asim, Alderazi, Sayed A, Aslam, Rumaisa, Barkat, Barooq, Barker, Bethan L, Bhat, Rahul, Cassidy, Samuel, Crowley, Louise E, Dosanjh, Davinder PS, Ebrahim, Hussain, Elndari, Najla, Gardiner, Claudia, Gogokhia, Atena, Grudzinska, Frances S, Gurung, Megha T, Hughes, Terry, Ismail, Iyad, Iredale, Natasha, Irshad, Sannaan, Johnson, Sarah, Kavanagh, Diana, Knight, Thomas, Livesey, Alana, Lugg, Sebastian T, Marathe, Manoj, McDougall, Andrew, Nawaz, Wasim, Nettleton, Kimberly, O’Flynn, Lauren, Okoth, Kelvin, Parekh, Dhruv, Perry, Rita, Pudney, Elizabeth J, Sadiq, Ambreen, Soge, Olutobi, Soloman, Rhania, Soltan, Marina, Strecker, Martin, Thein, Onn S, Thickett, David, Thomas, Ajit, Thornton, Riah
Format: Article
Language:English
Subjects:
Antibiotics
Blood pressure
collaborative
Coronaviruses
COVID-19
Cytokines
Data collection
Disease
Hospitals
Infections
Intensive care
Mortality
Observational studies
Original Research
Pandemics
Patients
Pneumonia
Sepsis
Severe acute respiratory syndrome coronavirus 2
severity score
Ventilators
Vital signs
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Summary:Severity scores in pneumonia and sepsis are being applied to SARS-CoV-2 infection. We aimed to assess whether these severity scores are accurate predictors of early adverse outcomes in COVID-19. We conducted a multicentre observational study of hospitalised SARS-CoV-2 infection. We assessed risk scores (CURB65, qSOFA, Lac-CURB65, MuLBSTA and NEWS2) in relation to admission to intensive care or death within 7 days of admission, defined as early severe adverse events (ESAE). The 4C Mortality Score was also assessed in a sub-cohort of patients. In 2,387 participants, the overall mortality was 18%. In all scores examined, increasing score was associated with increased risk of ESAE. Area under the curve (AUC) to predict ESAE for CURB65, qSOFA, Lac-CURB65, MuLBSTA and NEWS2 were 0.61, 0.62, 0.59, 0.59 and 0.68, respectively. AUC to predict ESAE was 0.60 with ISARIC 4C Mortality Score. None of the scores examined accurately predicted ESAE in SARS-CoV-2 infection. Non-validated scores should not be used to inform clinical decision making in COVID-19.
ISSN:1470-2118
1473-4893
DOI:10.7861/clinmed.2020-1107