Understanding the significance of biological clock and its impact on cancer incidence

The circadian clock is an essential timekeeper that controls, for humans, the daily rhythm of biochemical, physiological, and behavioral functions. Irregular performance or disruption in circadian rhythms results in various diseases, including cancer. As a factor in cancer development, perturbations...

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Bibliographic Details
Published in:Cancer letters 2022-02, Vol.527, p.80-94
Main Authors: Malik, Shalie, Stokes III, James, Manne, Upender, Singh, Rajesh, Mishra, Manoj K.
Format: Article
Language:English
Subjects:
Binding sites
Biological clock
Biological clocks
Cancer
Cell cycle
Chromatin remodeling
Chronotherapy
Circadian Clocks
Circadian rhythm
Circadian rhythms
Cyclin-dependent kinases
Energy balance
Feedback
Genes
Homeostasis
Hormones
Humans
Hypoxia
Incidence
Kinases
Mammals
Metabolism
Molecular mechanisms
Mutation
Neoplasms - epidemiology
Organisms
Pacemakers
Phosphorylation
Physiology
Proteins
Tumorigenesis
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Summary:The circadian clock is an essential timekeeper that controls, for humans, the daily rhythm of biochemical, physiological, and behavioral functions. Irregular performance or disruption in circadian rhythms results in various diseases, including cancer. As a factor in cancer development, perturbations in circadian rhythms can affect circadian homeostasis in energy balance, lead to alterations in the cell cycle, and cause dysregulation of chromatin remodeling. However, knowledge gaps remain in our understanding of the relationship between the circadian clock and cancer. Therefore, a mechanistic understanding by which circadian disruption enhances cancer risk is needed. This review article outlines the importance of the circadian clock in tumorigenesis and summarizes underlying mechanisms in the clock and its carcinogenic mechanisms, highlighting advances in chronotherapy for cancer treatment. •The endogenous circadian clock regulates various daily physiological and behavioral rhythms.•Circadian rhythm disruption (e.g., irregular work shifts and frequent travel across time zones) increases cancer initiation and progression risk.•Understanding the relationship between cancer and the circadian clock will help develop chronotherapeutic approaches to overcome cancer progression.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2021.12.006