Understanding the significance of biological clock and its impact on cancer incidence

• Published in: Cancer letters 2022-02, Vol.527, p.80-94
• Main Authors: Malik, Shalie, Stokes III, James, Manne, Upender, Singh, Rajesh, Mishra, Manoj K.
• Format: Article
• Language: English
• Subjects: Binding sites; Biological clock; Biological clocks; Cancer; Cell cycle; Chromatin remodeling; Chronotherapy; Circadian Clocks; Circadian rhythm; Circadian rhythms; Cyclin-dependent kinases; Energy balance; Feedback; Genes; Homeostasis; Hormones; Humans; Hypoxia; Incidence; Kinases; Mammals; Metabolism; Molecular mechanisms; Mutation; Neoplasms - epidemiology; Organisms; Pacemakers; Phosphorylation; Physiology; Proteins; Tumorigenesis
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2021.12.006

The circadian clock is an essential timekeeper that controls, for humans, the daily rhythm of biochemical, physiological, and behavioral functions. Irregular performance or disruption in circadian rhythms results in various diseases, including cancer. As a factor in cancer development, perturbations in circadian rhythms can affect circadian homeostasis in energy balance, lead to alterations in the cell cycle, and cause dysregulation of chromatin remodeling. However, knowledge gaps remain in our understanding of the relationship between the circadian clock and cancer. Therefore, a mechanistic understanding by which circadian disruption enhances cancer risk is needed. This review article outlines the importance of the circadian clock in tumorigenesis and summarizes underlying mechanisms in the clock and its carcinogenic mechanisms, highlighting advances in chronotherapy for cancer treatment. •The endogenous circadian clock regulates various daily physiological and behavioral rhythms.•Circadian rhythm disruption (e.g., irregular work shifts and frequent travel across time zones) increases cancer initiation and progression risk.•Understanding the relationship between cancer and the circadian clock will help develop chronotherapeutic approaches to overcome cancer progression.