Collagen mineralization with lepidocrocite via Fe(OH) 2 addition

The mineralization of collagen has been extensively investigated for hydroxyapatite, silica, calcium carbonate and lepidocrocite (γ-FeOOH). Henceforth, it is interesting to investigate whether collagen also could serve as a generic mineralization template for other minerals, like magnetite. To this...

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Bibliographic Details
Published in:CrystEngComm 2022-02, Vol.24 (6), p.1211-1217
Main Authors: Oosterlaken, Bernette M, van Rijt, Mark M J, Friedrich, Heiner, de With, Gijsbertus
Format: Article
Language:English
Subjects:
Aspartic acid
Calcium carbonate
Chemistry
Collagen
Ferrous hydroxide
Hydroxyapatite
Mineralization
Oxidation
Silicon dioxide
Titration
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Summary:The mineralization of collagen has been extensively investigated for hydroxyapatite, silica, calcium carbonate and lepidocrocite (γ-FeOOH). Henceforth, it is interesting to investigate whether collagen also could serve as a generic mineralization template for other minerals, like magnetite. To this end, and inspired by the partial oxidation approach, first a ferrous hydroxide (Fe(OH) ) intermediate is synthesized the titration of base to a solution of Fe . Subsequently, the Fe(OH) is mixed with collagen fibrils and poly(aspartic acid) is added to promote the formation of intrafibrillar crystals. Platelet-shaped lepidocrocite crystals being present throughout the entire thickness of the collagen fibrils can be realized, as was confirmed with electron tomography. The formation of lepidocrocite, which is an Fe compound, is hypothesized to be induced oxidation of the Fe species and, therefore, the oxygen concentration during titration, TEM sample preparation and drying of TEM samples are investigated. Although the reaction is sensitive to small changes in experimental conditions, highly mineralized collagen fibers can be realized.
ISSN:1466-8033
1466-8033
DOI:10.1039/d1ce01527c