Negative association between lipoprotein associated phospholipase A2 activity and baroreflex sensitivity in subjects with high normal blood pressure and a positive family history of hypertension

The relationship between baroreflex sensitivity (BRS) and inflammatory vascular biomarker Lipoprotein associated phospholipase A2 (Lp-PLA(2)) in subjects with high normal blood pressure (HNBP, prehypertensives) with a positive family history of hypertension (FHH+) and hypertension history free contr...

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Bibliographic Details
Published in:Physiological research 2021-04, Vol.70 (2), p.183-191
Main Authors: Čelovská, D, Vlčková, K, Gonsorčík, J
Format: Article
Language:English
Subjects:
Age
Antihypertensives
Automation
Baroreceptors
Biomarkers
Blood pressure
Body mass index
Cardiology
Diabetes
Disease
Family medical history
Females
Hypertension
Inflammation
Lipoproteins
Metabolism
Nervous system
Phospholipase A2
Reflexes
Single photon emission computed tomography
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Summary:The relationship between baroreflex sensitivity (BRS) and inflammatory vascular biomarker Lipoprotein associated phospholipase A2 (Lp-PLA(2)) in subjects with high normal blood pressure (HNBP, prehypertensives) with a positive family history of hypertension (FHH+) and hypertension history free control subjects (FHH-) was evaluated. A total of 24 HNBP participants (age 39.5 ± 2.5 years, 18 male/ 6 female) were studied. 14 HNBP subjects FHH+ were compared to 10 HNBP participants FHH-, being of similar age and body mass index. BRS (ms/mmHg) was determined by the sequence and spectral methods (five-minute non-invasive beat-to-beat recording of blood pressure and RR interval, controlled breathing at a frequency of 0.33 Hz). Venous blood was analyzed for Lp-PLA(2) biomarker of vascular inflammation and atherothrombotic activity. A significant negative correlation between spontaneous BRS obtained by both methods and systolic blood pressure (BP) was present (BRS spect r = –0.54, P
ISSN:0862-8408
1802-9973
DOI:10.33549/physiolres.934467