Physiologically Active Compounds Based on Membranotropic Cage Carriers–Derivatives of Adamantane and Polyhedral Boron Clusters (Review)

• Published in: Russian journal of inorganic chemistry 2022, Vol.67 (1), p.28-47
• Main Authors: Avdeeva, V. V., Garaev, T. M., Malinina, E. A., Zhizhin, K. Yu, Kuznetsov, N. T.
• Format: Article
• Language: English
• Subjects: Boron; Boron hydrides; Cage compounds; Chemistry; Chemistry and Materials Science; Clusters; Functional groups; Inhibitors; Inorganic Chemistry; Molecular structure; Synthesis and Properties of Inorganic Compounds
• ISSN: 0036-0236; 1531-8613
• DOI: 10.1134/S0036023622010028

Data on compounds based on cage structures―boron clusters (polyhedral boron hydrides, carboranes, metallacarboranes) and compounds of the adamantane series, which possess physiological activity, have been generalized. The main emphasis is placed on the antiviral activity of the compounds. The mechanism of the possible action of the replication inhibitors of influenza A virus strains is considered, the molecular model of viroporin inhibitors is discussed. The proposed model consists of a cage hydrophobic core that performs the function of a membranotropic carrier (a boron cluster or adamantane fragment), into which physiologically active functional groups are introduced. The relationship between the structure of the cage compound with the introduced substitute and the biologically active properties of this molecular structure has been analyzed.