Tacrolimus initial steady state level in post-transplant cyclophosphamide-based GvHD prophylaxis regimens

Post-transplant cyclophosphamide (PTCy) combined with tacrolimus (TAC) as graft-versus-host disease (GvHD) prophylaxis post-hematopoietic cell transplantation (HCT) is safe and effective. Optimal serum levels of TAC in this combination remain undetermined. We hypothesized that TAC at initial steady...

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Published in:Bone marrow transplantation (Basingstoke) 2022-02, Vol.57 (2), p.232-242
Main Authors: Yao, Janny M., Yang, Dongyun, Clark, Mary C., Otoukesh, Salman, Cao, Thai, Ali, Haris, Arslan, Shukaib, Aldoss, Ibrahim, Artz, Andrew, Amanam, Idoroenyi, Salhotra, Amandeep, Pullarkat, Vinod, Sandhu, Karamjeet, Stein, Anthony, Marcucci, Guido, Forman, Stephen J., Nakamura, Ryotaro, Al Malki, Monzr M.
Format: Article
Language:English
Subjects:
631/67/1059
692/308/575
Cell Biology
Cyclophosphamide
Cyclophosphamide - therapeutic use
Disease prevention
Graft versus host disease
Graft vs Host Disease - etiology
Graft-versus-host reaction
Health risks
Hematology
Hematopoietic Stem Cell Transplantation - adverse effects
Humans
Infections
Internal Medicine
Medicine
Medicine & Public Health
Neoplasm Recurrence, Local - drug therapy
Prophylaxis
Public Health
Retrospective Studies
Serum levels
Steady state
Stem cell transplantation
Stem Cells
Survival
Tacrolimus
Tacrolimus - therapeutic use
Toxicity
Transplantation
Transplants & implants
Viral infections
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Summary:Post-transplant cyclophosphamide (PTCy) combined with tacrolimus (TAC) as graft-versus-host disease (GvHD) prophylaxis post-hematopoietic cell transplantation (HCT) is safe and effective. Optimal serum levels of TAC in this combination remain undetermined. We hypothesized that TAC at initial steady state (TISS) of
ISSN:0268-3369
1476-5365
DOI:10.1038/s41409-021-01528-y