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Effects of ivabradine and atenolol on heart rate and heart rate variability in healthy cats over a 24 h period: A pilot study
Background Ivabradine is used to treat tachycardia; unlike atenolol, it does not affect blood pressure or myocardial contractility. This study compared the impact of ivabradine and atenolol on heart rate (HR) and HR variability (HRV) during a 24 h period, feeding and sleeping times, via a Holter ele...
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| Published in: | Veterinary record open 2022-12, Vol.9 (1), p.e28-n/a |
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| creator | Ogawa, Mizuki Kawamura, Ayano Akabane, Ryota Sakatani, Atsushi Miyakawa, Hirosumi Hsu, Huai‐Hsun Miyagawa, Yuichi Takemura, Naoyuki |
| description | Background
Ivabradine is used to treat tachycardia; unlike atenolol, it does not affect blood pressure or myocardial contractility. This study compared the impact of ivabradine and atenolol on heart rate (HR) and HR variability (HRV) during a 24 h period, feeding and sleeping times, via a Holter electrocardiogram in healthy cats. We hypothesised that ivabradine and atenolol would lower the HRs equally well, even at times of excitement and rest, such as during feeding and sleep; that ivabradine, unlike atenolol, would have an effect on HRV.
Methods
Five clinically healthy cats were used in the prospective blinded crossover study receiving 3 days of ivabradine (0.30 mg/kg per os twice daily) followed by atenolol (6.25 mg/cat per os twice daily, range 1.3–2.0 mg/kg) or receiving atenolol followed by ivabradine. A placebo period was initiated before the start of the crossover test, data obtained during that period were used as a baseline (BL). Evaluation parameters included HR and HRV, for the whole 24 h period and for feeding and sleeping times, comparing the effect of ivabradine and atenolol with BL.
Results
The HR for the whole 24 h, feeding and sleeping times, were significantly lower with ivabradine and atenolol, compared to BL (p |
| doi_str_mv | 10.1002/vro2.28 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8827492</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2628695466</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3928-1d9b9bacf5405be414f58330b2e78ef89aea88d1a6864e270b35a63a71919ee33</originalsourceid><addsrcrecordid>eNp1kd1qFTEQx4NYbKnFN5CAFwqybT52s4kXQin1AwoFUW_D7O6sJ5KzOSa7K3vjs_gsfbLm9NRSC71KMvPLjxn-hLzg7JgzJk7mGMSx0E_IgWCVKBTn8mm-S2OKXGD75Cgl1zBZM1XXqnxG9mXFq7LW1QH5c9732I6Jhp66GZoInRuQwtBRGHEIPngaBrpCiCONuXTTuvecITponHfjQt0N6MfVQlvYOmeMFKgor_6u6AajC907eko3zoeRpnHqludkrwef8Oj2PCTfPpx_PftUXFx-_Hx2elG00ghd8M40poG2r0pWNVjysq-0lKwRWGvstQEErTsOSqsSRc0aWYGSUHPDDaKUh-T9zruZmjV2LQ5jBG830a0hLjaAs_93BreyP8JstRZ1aUQWvLkVxPBrwjTatUsteg8DhilZoYRWpiqVyuirB-jPMMUhr2eFNowZpZjO1Osd1caQUsT-bhjO7DZWu401_8jky_uz33H_QszA2x3w23lcHvPY718uRdZdA5wsrPQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2890096608</pqid></control><display><type>article</type><title>Effects of ivabradine and atenolol on heart rate and heart rate variability in healthy cats over a 24 h period: A pilot study</title><source>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</source><source>Wiley Online Library Open Access</source><source>PubMed Central</source><creator>Ogawa, Mizuki ; Kawamura, Ayano ; Akabane, Ryota ; Sakatani, Atsushi ; Miyakawa, Hirosumi ; Hsu, Huai‐Hsun ; Miyagawa, Yuichi ; Takemura, Naoyuki</creator><creatorcontrib>Ogawa, Mizuki ; Kawamura, Ayano ; Akabane, Ryota ; Sakatani, Atsushi ; Miyakawa, Hirosumi ; Hsu, Huai‐Hsun ; Miyagawa, Yuichi ; Takemura, Naoyuki</creatorcontrib><description>Background
Ivabradine is used to treat tachycardia; unlike atenolol, it does not affect blood pressure or myocardial contractility. This study compared the impact of ivabradine and atenolol on heart rate (HR) and HR variability (HRV) during a 24 h period, feeding and sleeping times, via a Holter electrocardiogram in healthy cats. We hypothesised that ivabradine and atenolol would lower the HRs equally well, even at times of excitement and rest, such as during feeding and sleep; that ivabradine, unlike atenolol, would have an effect on HRV.
Methods
Five clinically healthy cats were used in the prospective blinded crossover study receiving 3 days of ivabradine (0.30 mg/kg per os twice daily) followed by atenolol (6.25 mg/cat per os twice daily, range 1.3–2.0 mg/kg) or receiving atenolol followed by ivabradine. A placebo period was initiated before the start of the crossover test, data obtained during that period were used as a baseline (BL). Evaluation parameters included HR and HRV, for the whole 24 h period and for feeding and sleeping times, comparing the effect of ivabradine and atenolol with BL.
Results
The HR for the whole 24 h, feeding and sleeping times, were significantly lower with ivabradine and atenolol, compared to BL (p < 0.05). The HRV for the whole 24 h and sleeping time were significantly higher after ivabradine compared with BL and after atenolol.
Conclusions
In healthy cats, ivabradine and atenolol significantly reduced the HR regardless of excitement and rest; their effects were comparable. Ivabradine significantly increased HRV in comparison to BL whereas atenolol did not.</description><identifier>ISSN: 2399-2050</identifier><identifier>ISSN: 2052-6113</identifier><identifier>EISSN: 2052-6113</identifier><identifier>DOI: 10.1002/vro2.28</identifier><identifier>PMID: 35154785</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Blood pressure ; Cardiomyopathy ; Cats ; Electrocardiography ; Heart failure ; Heart rate ; Ischemia ; Laboratory animals ; Nervous system ; Original Research ; Pacemakers ; Veterinary medicine</subject><ispartof>Veterinary record open, 2022-12, Vol.9 (1), p.e28-n/a</ispartof><rights>2022 The Authors. published by John Wiley & Sons Ltd on behalf of British Veterinary Association.</rights><rights>2022 The Authors. Veterinary Record Open published by John Wiley & Sons Ltd on behalf of British Veterinary Association.</rights><rights>2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3928-1d9b9bacf5405be414f58330b2e78ef89aea88d1a6864e270b35a63a71919ee33</cites><orcidid>0000-0001-5767-8363</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2890096608/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2890096608?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,11562,25753,27924,27925,37012,37013,44590,46052,46476,53791,53793,74998</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35154785$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ogawa, Mizuki</creatorcontrib><creatorcontrib>Kawamura, Ayano</creatorcontrib><creatorcontrib>Akabane, Ryota</creatorcontrib><creatorcontrib>Sakatani, Atsushi</creatorcontrib><creatorcontrib>Miyakawa, Hirosumi</creatorcontrib><creatorcontrib>Hsu, Huai‐Hsun</creatorcontrib><creatorcontrib>Miyagawa, Yuichi</creatorcontrib><creatorcontrib>Takemura, Naoyuki</creatorcontrib><title>Effects of ivabradine and atenolol on heart rate and heart rate variability in healthy cats over a 24 h period: A pilot study</title><title>Veterinary record open</title><addtitle>Vet Rec Open</addtitle><description>Background
Ivabradine is used to treat tachycardia; unlike atenolol, it does not affect blood pressure or myocardial contractility. This study compared the impact of ivabradine and atenolol on heart rate (HR) and HR variability (HRV) during a 24 h period, feeding and sleeping times, via a Holter electrocardiogram in healthy cats. We hypothesised that ivabradine and atenolol would lower the HRs equally well, even at times of excitement and rest, such as during feeding and sleep; that ivabradine, unlike atenolol, would have an effect on HRV.
Methods
Five clinically healthy cats were used in the prospective blinded crossover study receiving 3 days of ivabradine (0.30 mg/kg per os twice daily) followed by atenolol (6.25 mg/cat per os twice daily, range 1.3–2.0 mg/kg) or receiving atenolol followed by ivabradine. A placebo period was initiated before the start of the crossover test, data obtained during that period were used as a baseline (BL). Evaluation parameters included HR and HRV, for the whole 24 h period and for feeding and sleeping times, comparing the effect of ivabradine and atenolol with BL.
Results
The HR for the whole 24 h, feeding and sleeping times, were significantly lower with ivabradine and atenolol, compared to BL (p < 0.05). The HRV for the whole 24 h and sleeping time were significantly higher after ivabradine compared with BL and after atenolol.
Conclusions
In healthy cats, ivabradine and atenolol significantly reduced the HR regardless of excitement and rest; their effects were comparable. Ivabradine significantly increased HRV in comparison to BL whereas atenolol did not.</description><subject>Blood pressure</subject><subject>Cardiomyopathy</subject><subject>Cats</subject><subject>Electrocardiography</subject><subject>Heart failure</subject><subject>Heart rate</subject><subject>Ischemia</subject><subject>Laboratory animals</subject><subject>Nervous system</subject><subject>Original Research</subject><subject>Pacemakers</subject><subject>Veterinary medicine</subject><issn>2399-2050</issn><issn>2052-6113</issn><issn>2052-6113</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>PIMPY</sourceid><recordid>eNp1kd1qFTEQx4NYbKnFN5CAFwqybT52s4kXQin1AwoFUW_D7O6sJ5KzOSa7K3vjs_gsfbLm9NRSC71KMvPLjxn-hLzg7JgzJk7mGMSx0E_IgWCVKBTn8mm-S2OKXGD75Cgl1zBZM1XXqnxG9mXFq7LW1QH5c9732I6Jhp66GZoInRuQwtBRGHEIPngaBrpCiCONuXTTuvecITponHfjQt0N6MfVQlvYOmeMFKgor_6u6AajC907eko3zoeRpnHqludkrwef8Oj2PCTfPpx_PftUXFx-_Hx2elG00ghd8M40poG2r0pWNVjysq-0lKwRWGvstQEErTsOSqsSRc0aWYGSUHPDDaKUh-T9zruZmjV2LQ5jBG830a0hLjaAs_93BreyP8JstRZ1aUQWvLkVxPBrwjTatUsteg8DhilZoYRWpiqVyuirB-jPMMUhr2eFNowZpZjO1Osd1caQUsT-bhjO7DZWu401_8jky_uz33H_QszA2x3w23lcHvPY718uRdZdA5wsrPQ</recordid><startdate>202212</startdate><enddate>202212</enddate><creator>Ogawa, Mizuki</creator><creator>Kawamura, Ayano</creator><creator>Akabane, Ryota</creator><creator>Sakatani, Atsushi</creator><creator>Miyakawa, Hirosumi</creator><creator>Hsu, Huai‐Hsun</creator><creator>Miyagawa, Yuichi</creator><creator>Takemura, Naoyuki</creator><general>Blackwell Publishing Ltd</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5767-8363</orcidid></search><sort><creationdate>202212</creationdate><title>Effects of ivabradine and atenolol on heart rate and heart rate variability in healthy cats over a 24 h period: A pilot study</title><author>Ogawa, Mizuki ; Kawamura, Ayano ; Akabane, Ryota ; Sakatani, Atsushi ; Miyakawa, Hirosumi ; Hsu, Huai‐Hsun ; Miyagawa, Yuichi ; Takemura, Naoyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3928-1d9b9bacf5405be414f58330b2e78ef89aea88d1a6864e270b35a63a71919ee33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Blood pressure</topic><topic>Cardiomyopathy</topic><topic>Cats</topic><topic>Electrocardiography</topic><topic>Heart failure</topic><topic>Heart rate</topic><topic>Ischemia</topic><topic>Laboratory animals</topic><topic>Nervous system</topic><topic>Original Research</topic><topic>Pacemakers</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ogawa, Mizuki</creatorcontrib><creatorcontrib>Kawamura, Ayano</creatorcontrib><creatorcontrib>Akabane, Ryota</creatorcontrib><creatorcontrib>Sakatani, Atsushi</creatorcontrib><creatorcontrib>Miyakawa, Hirosumi</creatorcontrib><creatorcontrib>Hsu, Huai‐Hsun</creatorcontrib><creatorcontrib>Miyagawa, Yuichi</creatorcontrib><creatorcontrib>Takemura, Naoyuki</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Online Library Free Content</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Veterinary record open</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ogawa, Mizuki</au><au>Kawamura, Ayano</au><au>Akabane, Ryota</au><au>Sakatani, Atsushi</au><au>Miyakawa, Hirosumi</au><au>Hsu, Huai‐Hsun</au><au>Miyagawa, Yuichi</au><au>Takemura, Naoyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of ivabradine and atenolol on heart rate and heart rate variability in healthy cats over a 24 h period: A pilot study</atitle><jtitle>Veterinary record open</jtitle><addtitle>Vet Rec Open</addtitle><date>2022-12</date><risdate>2022</risdate><volume>9</volume><issue>1</issue><spage>e28</spage><epage>n/a</epage><pages>e28-n/a</pages><issn>2399-2050</issn><issn>2052-6113</issn><eissn>2052-6113</eissn><abstract>Background
Ivabradine is used to treat tachycardia; unlike atenolol, it does not affect blood pressure or myocardial contractility. This study compared the impact of ivabradine and atenolol on heart rate (HR) and HR variability (HRV) during a 24 h period, feeding and sleeping times, via a Holter electrocardiogram in healthy cats. We hypothesised that ivabradine and atenolol would lower the HRs equally well, even at times of excitement and rest, such as during feeding and sleep; that ivabradine, unlike atenolol, would have an effect on HRV.
Methods
Five clinically healthy cats were used in the prospective blinded crossover study receiving 3 days of ivabradine (0.30 mg/kg per os twice daily) followed by atenolol (6.25 mg/cat per os twice daily, range 1.3–2.0 mg/kg) or receiving atenolol followed by ivabradine. A placebo period was initiated before the start of the crossover test, data obtained during that period were used as a baseline (BL). Evaluation parameters included HR and HRV, for the whole 24 h period and for feeding and sleeping times, comparing the effect of ivabradine and atenolol with BL.
Results
The HR for the whole 24 h, feeding and sleeping times, were significantly lower with ivabradine and atenolol, compared to BL (p < 0.05). The HRV for the whole 24 h and sleeping time were significantly higher after ivabradine compared with BL and after atenolol.
Conclusions
In healthy cats, ivabradine and atenolol significantly reduced the HR regardless of excitement and rest; their effects were comparable. Ivabradine significantly increased HRV in comparison to BL whereas atenolol did not.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>35154785</pmid><doi>10.1002/vro2.28</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-5767-8363</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 2399-2050 |
| ispartof | Veterinary record open, 2022-12, Vol.9 (1), p.e28-n/a |
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| source | Publicly Available Content Database (Proquest) (PQ_SDU_P3); Wiley Online Library Open Access; PubMed Central |
| subjects | Blood pressure Cardiomyopathy Cats Electrocardiography Heart failure Heart rate Ischemia Laboratory animals Nervous system Original Research Pacemakers Veterinary medicine |
| title | Effects of ivabradine and atenolol on heart rate and heart rate variability in healthy cats over a 24 h period: A pilot study |
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