A Traditional Chinese Medicine for the Treatment of Endometrial Hyperplasia via Regulating the HPO Axis in Rats

Dysfunctional uterine bleeding, accompanied by endometrial hyperplasia (EH), is a common gynecological disease that seriously affects female physical and mental health. Some drugs have been prompted to cure the disease, but most medications have certain side effects and limitations. In the present s...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2022, Vol.2022, p.5200608-13
Main Authors: Lv, Bo, Peng, Yuan-de, Fu, Wen-hui, Li, Wen-jing, Chen, Li-jun, Wang, Zhi
Format: Article
Language:English
Subjects:
Chinese medicine
Chromatography
Drug dosages
Endometrium
Estrogens
Ethanol
Fertility
Follicle-stimulating hormone
Gene expression
Gynecological diseases
High-performance liquid chromatography
Hormones
Hyperplasia
Laboratory animals
Luteinizing hormone
Matrix metalloproteinase
Medical research
Metalloproteinase
Progesterone
Thin-layer chromatography
Traditional Chinese medicine
Uterus
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Summary:Dysfunctional uterine bleeding, accompanied by endometrial hyperplasia (EH), is a common gynecological disease that seriously affects female physical and mental health. Some drugs have been prompted to cure the disease, but most medications have certain side effects and limitations. In the present study, we demonstrated an unexploited Chinese traditional medicine, a combination of Saururus chinensis, Celosia cristata, and Spatholobus suberectus (SCS), which could be used for the treatment of EH and associated complications in rats. We identified the active components from the three Chinese herbs via thin-layer chromatography and high-performance liquid chromatography methods. In addition, serum biochemical indexes and histologic section results found that acute high-dose SCS exerted no adverse impacts on the rats. We then showed that SCS shortened coagulation time (p=0.018) and degree of swelling (p=0.021) on rats at 30 min compared to blank control. Further studies proved that recovered endometrial thickness was associated with the modulation of four hormones (follicle-stimulating hormone, luteinizing hormone, estrogen, and progesterone). Specifically, follicle-stimulating hormone and progesterone contents increased gradually with time, and estrogen was decreased, whereas luteinizing hormone content was returned to normal after a short-term elevation (p
ISSN:1741-427X
1741-4288
DOI:10.1155/2022/5200608