Effects of testosterone on rat placental development

We investigated the morphological effects of testosterone on placental development in a rat model of polycystic ovarian syndrome (PCOS). Testosterone propionate (TP), which was subcutaneously administered to pregnant rats with 5 mg/animal from gestation day (GD) 14 to GD 18, induced a maternal weigh...

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Bibliographic Details
Published in:Journal of Toxicologic Pathology 2022, Vol.35(1), pp.37-44
Main Authors: Furukawa, Satoshi, Tsuji, Naho, Hayashi, Seigo, Kuroda, Yusuke, Kimura, Masayuki, Hayakawa, Chisato, Takeuchi, Kazuya, Sugiyama, Akihiko
Format: Article
Language:English
Subjects:
Fetuses
Growth rate
IUGR
labyrinth zone
Morphology
Original
PCOS
Placenta
Polycystic ovary syndrome
Propionic acid
Septum
small placenta
Testosterone
Testosterone propionate
trophoblast
Weight reduction
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Summary:We investigated the morphological effects of testosterone on placental development in a rat model of polycystic ovarian syndrome (PCOS). Testosterone propionate (TP), which was subcutaneously administered to pregnant rats with 5 mg/animal from gestation day (GD) 14 to GD 18, induced a maternal weight reduction without mortality or clinical signs from GD 19 onwards. A decrease in fetal and placental weight, an increase in intrauterine growth retardation (IUGR) rates, and histological changes in the placenta were observed on GD 21 but not on GD15 or 17. Histopathologically, on GD 21, the trophoblast septa thickened, and the maternal sinusoids were narrowed in the labyrinth zone, resulting in a small placenta. Additionally, the placental weight, thickness, and histological morphology in the labyrinth zone on GD 21 in the TP-treated group were nearly identical to those on GD 17 in the control and TP-treated groups. Therefore, it was assumed that the testosterone-induced small placenta was induced in association with the developmental inhibition of the fetal part of the placentas from GD 17 onwards.
ISSN:0914-9198
1881-915X
1347-7404
DOI:10.1293/tox.2021-0035