Minimal Information about MHC Multimers (MIAMM)

With the goal of improving the reproducibility and annotatability of MHC multimer reagent data, we present the establishment of a new data standard: Minimal Information about MHC Multimers (https://miamm.lji.org/). Multimers are engineered reagents composed of a ligand and a MHC, which can be repres...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2022-02, Vol.208 (3), p.531-537
Main Authors: Vita, Randi, Mody, Apurva, Overton, James A, Buus, Soren, Haley, Stephen T, Sette, Alessandro, Mallajosyula, Vamsee, Davis, Mark M, Long, Dale L, Willis, Richard A, Peters, Bjoern, Altman, John D
Format: Article
Language:English
Subjects:
HLA-A Antigens - immunology
Humans
Indicators and Reagents - chemistry
Internet
Major Histocompatibility Complex - genetics
Multiprotein Complexes - chemistry
T-Lymphocytes - immunology
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Summary:With the goal of improving the reproducibility and annotatability of MHC multimer reagent data, we present the establishment of a new data standard: Minimal Information about MHC Multimers (https://miamm.lji.org/). Multimers are engineered reagents composed of a ligand and a MHC, which can be represented in a standardized format using ontology terminology. We provide an online Web site to host the details of the standard, as well as a validation tool to assist with the adoption of the standard. We hope that this publication will bring increased awareness of Minimal Information about MHC Multimers and drive acceptance, ultimately improving the quality and documentation of multimer data in the scientific literature.
ISSN:0022-1767
1550-6606
1550-6606
DOI:10.4049/jimmunol.2100961