Complex decay dynamics of HIV virions, intact and defective proviruses, and 2LTR circles following initiation of antiretroviral therapy

In persons living with HIV-1 (PLWH) who start antiretroviral therapy (ART), plasma virus decays in a biphasic fashion to below the detection limit. The first phase reflects the short half-life (

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2022-02, Vol.119 (6), p.1-9
Main Authors: White, Jennifer A., Simonetti, Francesco R., Beg, Subul, McMyn, Natalie F., Dai, Weiwei, Bachmann, Niklas, Lai, Jun, Ford, William C., Bunch, Christina, Jones, Joyce L., Ribeiro, Ruy. M., Perelson, Alan S., Siliciano, Janet D., Siliciano, Robert F.
Format: Article
Language:English
Subjects:
2LTR circles
60 APPLIED LIFE SCIENCES
Anti-Retroviral Agents - pharmacology
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
biological science
Biological Sciences
CD4 antigen
CD4-Positive T-Lymphocytes - drug effects
Cells, Cultured
Decay
decay processes
Decay rate
DNA, Viral - drug effects
Drug therapy
Genomes
Half-life
HIV
HIV Infections - drug therapy
HIV-1 - drug effects
Human immunodeficiency virus
Humans
IPDA
Latency
Latent infection
latent reservoir
Long terminal repeat
Longitudinal Studies
Lymphocytes
Lymphocytes T
Proviruses
Proviruses - drug effects
viral dynamics
Viral Load - drug effects
Virion - drug effects
Virions
Virus Latency - drug effects
Virus Replication - drug effects
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Description
Summary:In persons living with HIV-1 (PLWH) who start antiretroviral therapy (ART), plasma virus decays in a biphasic fashion to below the detection limit. The first phase reflects the short half-life (
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.2120326119