Serum Sestrin-1 Concentration Is Higher in Frail than Non-Frail Older People Living in Nursing Homes

Given the increasing prevalence of frailty and its implications for public health, the identification of biomarkers to detect frailty is essential. Sestrin-1 is a protein with a protective role in muscle function. This study aimed to determine whether the serum sestrin-1 concentration differed betwe...

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Published in:International journal of environmental research and public health 2022-01, Vol.19 (3), p.1079
Main Authors: Sanz, Begoña, Rezola-Pardo, Chloe, Arrieta, Haritz, Fraile-Bermúdez, Ana Belén, Alonso-Puyo, Janire, Molano, Irene, Rodriguez-Larrad, Ana, Irazusta, Jon
Format: Article
Language:English
Subjects:
Aged
Anthropometry
Biomarkers
Exercise
Female
Frail Elderly
Frailty
Frailty - diagnosis
Geriatric Assessment - methods
Heat-Shock Proteins
Humans
Male
Muscles
Nursing Homes
Older people
Phenotypes
Physical activity
Public health
Sestrins
Statistical models
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Summary:Given the increasing prevalence of frailty and its implications for public health, the identification of biomarkers to detect frailty is essential. Sestrin-1 is a protein with a protective role in muscle function. This study aimed to determine whether the serum sestrin-1 concentration differed between frail and non-frail populations and to investigate its association with frailty-related variables in 225 older women and men living in nursing homes (Gipuzkoa, Spain). Serum sestrin-1 concentration was measured by ELISA. Frailty, dependence, anthropometry, physical function, and physical activity were determined by validated tests and tools. The associations between sestrin-1 concentration and the other variables were determined using generalized linear models. The differences between frail and non-frail individuals were analyzed by the Mann-Whitney U-test, and receiver operating characteristic (ROC) curves were constructed to calculate the capability of sestrin-1 to detect frailty. Unexpectedly, frail individuals-according to the Fried Frailty Phenotype or the Clinical Frailty Scale-had higher serum sestrin-1 concentrations than non-frail individuals. Furthermore, the higher serum sestrin-1 concentration was associated with the increased frailty scores and dependence as well as the poorer physical function and the less physical activity. Given the contradictory results regarding serum sestrin-1 and frailty, further investigation is required to propose it as a molecular biomarker of frailty.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph19031079