Role of the Transcription Factor FOSL1 in Organ Development and Tumorigenesis

The transcription factor FOSL1 plays an important role in cell differentiation and tumorigenesis. Primarily, FOSL1 is crucial for the differentiation of several cell lineages, namely adipocytes, chondrocytes, and osteoblasts. In solid tumors, FOSL1 controls the progression of tumor cells through the...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-01, Vol.23 (3), p.1521
Main Authors: Sobolev, Vladimir V, Khashukoeva, Asiat Z, Evina, Olga E, Geppe, Natalia A, Chebysheva, Svetlana N, Korsunskaya, Irina M, Tchepourina, Ekaterina, Mezentsev, Alexandre
Format: Article
Language:English
Subjects:
Adipocytes
Animals
Binding sites
Biomedical materials
Biosynthesis
Cancer
Carcinogenesis - genetics
Carcinogenesis - metabolism
Cell Differentiation
Cell Proliferation
Chondrocytes
Chondrogenesis
Cytoplasm
Differentiation (biology)
Epithelial-Mesenchymal Transition
Gene expression
Gene Expression Regulation, Neoplastic
Genetic modification
Humans
Intracellular signalling
Kinases
Mesenchyme
Mice
Mutation
Osteoblastogenesis
Phosphorylation
Protein Stability
Proteins
Proteolysis
Proto-Oncogene Proteins c-fos - chemistry
Proto-Oncogene Proteins c-fos - genetics
Proto-Oncogene Proteins c-fos - metabolism
Review
Solid tumors
Transcription factors
Tumor cells
Tumorigenesis
Tumors
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Summary:The transcription factor FOSL1 plays an important role in cell differentiation and tumorigenesis. Primarily, FOSL1 is crucial for the differentiation of several cell lineages, namely adipocytes, chondrocytes, and osteoblasts. In solid tumors, FOSL1 controls the progression of tumor cells through the epithelial-mesenchymal transformation. In this review, we summarize the available data on FOSL1 expression, stabilization, and degradation in the cell. We discuss how FOSL1 is integrated into the intracellular signaling mechanisms and provide a comprehensive analysis of FOSL1 influence on gene expression. We also analyze the pathological changes caused by altered expression in genetically modified mice. In addition, we dedicated a separate section of the review to the role of FOSL1 in human cancer. Primarily, we focus on the expression pattern in solid tumors, FOSL1 importance as a prognostic factor, and FOSL1 perspectives as a molecular target for anticancer therapy.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23031521