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Role of the Transcription Factor FOSL1 in Organ Development and Tumorigenesis
The transcription factor FOSL1 plays an important role in cell differentiation and tumorigenesis. Primarily, FOSL1 is crucial for the differentiation of several cell lineages, namely adipocytes, chondrocytes, and osteoblasts. In solid tumors, FOSL1 controls the progression of tumor cells through the...
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| Published in: | International journal of molecular sciences 2022-01, Vol.23 (3), p.1521 |
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| container_issue | 3 |
| container_start_page | 1521 |
| container_title | International journal of molecular sciences |
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| creator | Sobolev, Vladimir V Khashukoeva, Asiat Z Evina, Olga E Geppe, Natalia A Chebysheva, Svetlana N Korsunskaya, Irina M Tchepourina, Ekaterina Mezentsev, Alexandre |
| description | The transcription factor FOSL1 plays an important role in cell differentiation and tumorigenesis. Primarily, FOSL1 is crucial for the differentiation of several cell lineages, namely adipocytes, chondrocytes, and osteoblasts. In solid tumors, FOSL1 controls the progression of tumor cells through the epithelial-mesenchymal transformation. In this review, we summarize the available data on FOSL1 expression, stabilization, and degradation in the cell. We discuss how FOSL1 is integrated into the intracellular signaling mechanisms and provide a comprehensive analysis of FOSL1 influence on gene expression. We also analyze the pathological changes caused by altered
expression in genetically modified mice. In addition, we dedicated a separate section of the review to the role of FOSL1 in human cancer. Primarily, we focus on the
expression pattern in solid tumors, FOSL1 importance as a prognostic factor, and FOSL1 perspectives as a molecular target for anticancer therapy. |
| doi_str_mv | 10.3390/ijms23031521 |
| format | article |
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expression in genetically modified mice. In addition, we dedicated a separate section of the review to the role of FOSL1 in human cancer. Primarily, we focus on the
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expression in genetically modified mice. In addition, we dedicated a separate section of the review to the role of FOSL1 in human cancer. Primarily, we focus on the
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chemistry</subject><subject>Proto-Oncogene Proteins c-fos - genetics</subject><subject>Proto-Oncogene Proteins c-fos - metabolism</subject><subject>Review</subject><subject>Solid tumors</subject><subject>Transcription factors</subject><subject>Tumor cells</subject><subject>Tumorigenesis</subject><subject>Tumors</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpdkU1LAzEQhoMoft88S8CLB6v52GSzF0GqVaFS0HoOaXa2puwmNdkV_PdusUp1DjMD88zLDC9CJ5Rccl6QK7doEuOEU8HoFtqnGWMDQmS-vdHvoYOUFoQwzkSxi_a4oJJnWbaPnp5DDThUuH0DPI3GJxvdsnXB45GxbYh4NHkZU-w8nsS58fgWPqAOywZ8i40v8bRrQnRz8JBcOkI7lakTHK_rIXod3U2HD4Px5P5xeDMe2CxXbZ8BZpVRtsooZ1bxsgJZWpgpUdg-iBFgM16VQgjGirKwitqK5FTJUtpM8UN0_a277GYN9Ju-jabWy-gaEz91ME7_nXj3pufhQyvFRS5kL3C-FojhvYPU6sYlC3VtPIQuaSZZQUQuFe3Rs3_oInTR9--tqFxKSSnvqYtvysaQUoTq9xhK9MonvelTj59uPvAL_xjDvwC2iY9o</recordid><startdate>20220128</startdate><enddate>20220128</enddate><creator>Sobolev, Vladimir V</creator><creator>Khashukoeva, Asiat Z</creator><creator>Evina, Olga E</creator><creator>Geppe, Natalia A</creator><creator>Chebysheva, Svetlana N</creator><creator>Korsunskaya, Irina M</creator><creator>Tchepourina, Ekaterina</creator><creator>Mezentsev, Alexandre</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4779-156X</orcidid></search><sort><creationdate>20220128</creationdate><title>Role of the Transcription Factor FOSL1 in Organ Development and Tumorigenesis</title><author>Sobolev, Vladimir V ; Khashukoeva, Asiat Z ; Evina, Olga E ; Geppe, Natalia A ; Chebysheva, Svetlana N ; Korsunskaya, Irina M ; Tchepourina, Ekaterina ; Mezentsev, Alexandre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-c4eebfa8cf4132c83dfe6dceb859cccc0a5ec43fd555229d9c81cf07186d6c483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adipocytes</topic><topic>Animals</topic><topic>Binding sites</topic><topic>Biomedical materials</topic><topic>Biosynthesis</topic><topic>Cancer</topic><topic>Carcinogenesis - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sobolev, Vladimir V</au><au>Khashukoeva, Asiat Z</au><au>Evina, Olga E</au><au>Geppe, Natalia A</au><au>Chebysheva, Svetlana N</au><au>Korsunskaya, Irina M</au><au>Tchepourina, Ekaterina</au><au>Mezentsev, Alexandre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of the Transcription Factor FOSL1 in Organ Development and Tumorigenesis</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2022-01-28</date><risdate>2022</risdate><volume>23</volume><issue>3</issue><spage>1521</spage><pages>1521-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>The transcription factor FOSL1 plays an important role in cell differentiation and tumorigenesis. Primarily, FOSL1 is crucial for the differentiation of several cell lineages, namely adipocytes, chondrocytes, and osteoblasts. In solid tumors, FOSL1 controls the progression of tumor cells through the epithelial-mesenchymal transformation. In this review, we summarize the available data on FOSL1 expression, stabilization, and degradation in the cell. We discuss how FOSL1 is integrated into the intracellular signaling mechanisms and provide a comprehensive analysis of FOSL1 influence on gene expression. We also analyze the pathological changes caused by altered
expression in genetically modified mice. In addition, we dedicated a separate section of the review to the role of FOSL1 in human cancer. Primarily, we focus on the
expression pattern in solid tumors, FOSL1 importance as a prognostic factor, and FOSL1 perspectives as a molecular target for anticancer therapy.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35163444</pmid><doi>10.3390/ijms23031521</doi><orcidid>https://orcid.org/0000-0003-4779-156X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adipocytes Animals Binding sites Biomedical materials Biosynthesis Cancer Carcinogenesis - genetics Carcinogenesis - metabolism Cell Differentiation Cell Proliferation Chondrocytes Chondrogenesis Cytoplasm Differentiation (biology) Epithelial-Mesenchymal Transition Gene expression Gene Expression Regulation, Neoplastic Genetic modification Humans Intracellular signalling Kinases Mesenchyme Mice Mutation Osteoblastogenesis Phosphorylation Protein Stability Proteins Proteolysis Proto-Oncogene Proteins c-fos - chemistry Proto-Oncogene Proteins c-fos - genetics Proto-Oncogene Proteins c-fos - metabolism Review Solid tumors Transcription factors Tumor cells Tumorigenesis Tumors |
| title | Role of the Transcription Factor FOSL1 in Organ Development and Tumorigenesis |
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