Immunomodulatory Activity of the Most Commonly Used Antihypertensive Drugs-Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers

This review article is focused on antihypertensive drugs, namely angiotensin converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB), and their immunomodulatory properties reported in hypertensive patients as well as in experimental settings involving studies on animal models...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-02, Vol.23 (3), p.1772
Main Authors: Bryniarski, Paweł, Nazimek, Katarzyna, Marcinkiewicz, Janusz
Format: Article
Language:English
Subjects:
Angiotensin
Angiotensin II
Angiotensin Receptor Antagonists - pharmacology
Angiotensin-converting enzyme inhibitors
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Animal models
Animals
Antidepressants
Antihypertensive Agents - pharmacology
Antihypertensives
Atherosclerosis
Autoimmune diseases
Blood levels
Blood plasma
Blood pressure
Cardiovascular disease
Cell culture
Cell lines
Chronic illnesses
Conversion
Coronary vessels
COVID-19
Cytokines
Diuretics
Drug dosages
Enzymes
Gene expression
Heart attacks
Heart failure
Humans
Hyperkalemia
Hypertension
Immune system
Immunomodulation
Immunomodulation - drug effects
Immunomodulators
Immunosuppressive agents
Inflammation
Metabolic disorders
Metabolic syndrome
Pancreatitis
Patients
Peptidyl-dipeptidase A
Radiation
Review
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Summary:This review article is focused on antihypertensive drugs, namely angiotensin converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB), and their immunomodulatory properties reported in hypertensive patients as well as in experimental settings involving studies on animal models and cell lines. The immune regulatory action of ACEI and ARB is mainly connected with the inhibition of proinflammatory cytokine secretion, diminished expression of adhesion molecules, and normalization of CRP concentration in the blood plasma. The topic has significant importance in future medical practice in the therapy of patients with comorbidities with underlying chronic inflammatory responses. Thus, this additional effect of immune regulatory action of ACEI and ARB may also benefit the treatment of patients with metabolic syndrome, allergies, or autoimmune disorders.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23031772