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Intraspecific Diversity of Microbial Anti-Inflammatory Molecule (MAM) from Faecalibacterium prausnitzii
The commensal bacterium has unique anti-inflammatory properties, at least some of which have been attributed to its production of MAM, the Microbial Anti-inflammatory Molecule. Previous phylogenetic studies of strains have revealed the existence of various phylogroups. In this work, we address the q...
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| Published in: | International journal of molecular sciences 2022-02, Vol.23 (3), p.1705 |
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| creator | Auger, Sandrine Kropp, Camille Borras-Nogues, Esther Chanput, Wasaporn Andre-Leroux, Gwenaelle Gitton-Quent, Oscar Benevides, Leandro Breyner, Natalia Azevedo, Vasco Langella, Philippe Chatel, Jean-Marc |
| description | The commensal bacterium
has unique anti-inflammatory properties, at least some of which have been attributed to its production of MAM, the Microbial Anti-inflammatory Molecule. Previous phylogenetic studies of
strains have revealed the existence of various phylogroups. In this work, we address the question of whether MAMs from different phylogroups display distinct anti-inflammatory properties. We first performed wide-scale identification, classification, and phylogenetic analysis of MAM-like proteins encoded in different genomes of
. When combined with a gene context analysis, this approach distinguished at least 10 distinct clusters of MAMs, providing evidence for functional diversity within this protein. We then selected 11 MAMs from various clusters and evaluated their anti-inflammatory capacities in vitro. A wide range of anti-inflammatory activity was detected. MAM from the M21/2 strain had the highest inhibitory effect (96% inhibition), while MAM from reference strain A2-165 demonstrated only 56% inhibition, and MAM from strain CNCM4541 was almost inactive. These results were confirmed in vivo in murine models of acute and chronic colitis. This study provides insights into the family of MAM proteins and generates clues regarding the choice of
strains as probiotics for use in targeting chronic inflammatory diseases. |
| doi_str_mv | 10.3390/ijms23031705 |
| format | article |
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has unique anti-inflammatory properties, at least some of which have been attributed to its production of MAM, the Microbial Anti-inflammatory Molecule. Previous phylogenetic studies of
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. When combined with a gene context analysis, this approach distinguished at least 10 distinct clusters of MAMs, providing evidence for functional diversity within this protein. We then selected 11 MAMs from various clusters and evaluated their anti-inflammatory capacities in vitro. A wide range of anti-inflammatory activity was detected. MAM from the M21/2 strain had the highest inhibitory effect (96% inhibition), while MAM from reference strain A2-165 demonstrated only 56% inhibition, and MAM from strain CNCM4541 was almost inactive. These results were confirmed in vivo in murine models of acute and chronic colitis. This study provides insights into the family of MAM proteins and generates clues regarding the choice of
strains as probiotics for use in targeting chronic inflammatory diseases.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms23031705</identifier><identifier>PMID: 35163630</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animal models ; Animals ; Anti-inflammatory agents ; Anti-Inflammatory Agents - therapeutic use ; Bacterial Proteins - chemistry ; Bacterial Proteins - genetics ; Bacterial Proteins - therapeutic use ; Bacteriology ; Base Sequence ; Binding sites ; Biochemistry, Molecular Biology ; Cluster analysis ; Colitis ; Colitis - drug therapy ; Datasets ; Faecalibacterium prausnitzii ; Faecalibacterium prausnitzii - genetics ; Faecalibacterium prausnitzii - metabolism ; Genes ; Genetic Variation ; Genome, Bacterial ; Genomes ; In vivo methods and tests ; Inflammatory diseases ; Life Sciences ; Male ; Mice ; Microbiology and Parasitology ; Microorganisms ; Phylogenetics ; Phylogeny ; Probiotics ; Probiotics - therapeutic use ; Proteins ; Sequence Analysis, DNA</subject><ispartof>International journal of molecular sciences, 2022-02, Vol.23 (3), p.1705</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Attribution</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-9b7971fdf829285b6993c457975f5f89b12e25737d85bad1448eea8514565f093</citedby><cites>FETCH-LOGICAL-c512t-9b7971fdf829285b6993c457975f5f89b12e25737d85bad1448eea8514565f093</cites><orcidid>0000-0001-7650-9506 ; 0000-0002-4775-2280 ; 0000-0001-6814-7859 ; 0000-0003-4967-1414 ; 0000-0002-7915-1666 ; 0000-0003-2139-4320</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2627722535/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2627722535?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25731,27901,27902,36989,36990,44566,53766,53768,74869</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35163630$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-03752257$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Auger, Sandrine</creatorcontrib><creatorcontrib>Kropp, Camille</creatorcontrib><creatorcontrib>Borras-Nogues, Esther</creatorcontrib><creatorcontrib>Chanput, Wasaporn</creatorcontrib><creatorcontrib>Andre-Leroux, Gwenaelle</creatorcontrib><creatorcontrib>Gitton-Quent, Oscar</creatorcontrib><creatorcontrib>Benevides, Leandro</creatorcontrib><creatorcontrib>Breyner, Natalia</creatorcontrib><creatorcontrib>Azevedo, Vasco</creatorcontrib><creatorcontrib>Langella, Philippe</creatorcontrib><creatorcontrib>Chatel, Jean-Marc</creatorcontrib><title>Intraspecific Diversity of Microbial Anti-Inflammatory Molecule (MAM) from Faecalibacterium prausnitzii</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>The commensal bacterium
has unique anti-inflammatory properties, at least some of which have been attributed to its production of MAM, the Microbial Anti-inflammatory Molecule. Previous phylogenetic studies of
strains have revealed the existence of various phylogroups. In this work, we address the question of whether MAMs from different phylogroups display distinct anti-inflammatory properties. We first performed wide-scale identification, classification, and phylogenetic analysis of MAM-like proteins encoded in different genomes of
. When combined with a gene context analysis, this approach distinguished at least 10 distinct clusters of MAMs, providing evidence for functional diversity within this protein. We then selected 11 MAMs from various clusters and evaluated their anti-inflammatory capacities in vitro. A wide range of anti-inflammatory activity was detected. MAM from the M21/2 strain had the highest inhibitory effect (96% inhibition), while MAM from reference strain A2-165 demonstrated only 56% inhibition, and MAM from strain CNCM4541 was almost inactive. These results were confirmed in vivo in murine models of acute and chronic colitis. This study provides insights into the family of MAM proteins and generates clues regarding the choice of
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has unique anti-inflammatory properties, at least some of which have been attributed to its production of MAM, the Microbial Anti-inflammatory Molecule. Previous phylogenetic studies of
strains have revealed the existence of various phylogroups. In this work, we address the question of whether MAMs from different phylogroups display distinct anti-inflammatory properties. We first performed wide-scale identification, classification, and phylogenetic analysis of MAM-like proteins encoded in different genomes of
. When combined with a gene context analysis, this approach distinguished at least 10 distinct clusters of MAMs, providing evidence for functional diversity within this protein. We then selected 11 MAMs from various clusters and evaluated their anti-inflammatory capacities in vitro. A wide range of anti-inflammatory activity was detected. MAM from the M21/2 strain had the highest inhibitory effect (96% inhibition), while MAM from reference strain A2-165 demonstrated only 56% inhibition, and MAM from strain CNCM4541 was almost inactive. These results were confirmed in vivo in murine models of acute and chronic colitis. This study provides insights into the family of MAM proteins and generates clues regarding the choice of
strains as probiotics for use in targeting chronic inflammatory diseases.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35163630</pmid><doi>10.3390/ijms23031705</doi><orcidid>https://orcid.org/0000-0001-7650-9506</orcidid><orcidid>https://orcid.org/0000-0002-4775-2280</orcidid><orcidid>https://orcid.org/0000-0001-6814-7859</orcidid><orcidid>https://orcid.org/0000-0003-4967-1414</orcidid><orcidid>https://orcid.org/0000-0002-7915-1666</orcidid><orcidid>https://orcid.org/0000-0003-2139-4320</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animal models Animals Anti-inflammatory agents Anti-Inflammatory Agents - therapeutic use Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - therapeutic use Bacteriology Base Sequence Binding sites Biochemistry, Molecular Biology Cluster analysis Colitis Colitis - drug therapy Datasets Faecalibacterium prausnitzii Faecalibacterium prausnitzii - genetics Faecalibacterium prausnitzii - metabolism Genes Genetic Variation Genome, Bacterial Genomes In vivo methods and tests Inflammatory diseases Life Sciences Male Mice Microbiology and Parasitology Microorganisms Phylogenetics Phylogeny Probiotics Probiotics - therapeutic use Proteins Sequence Analysis, DNA |
| title | Intraspecific Diversity of Microbial Anti-Inflammatory Molecule (MAM) from Faecalibacterium prausnitzii |
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