The Role of Sclerostin in Bone Diseases

Sclerostin has been identified as an important regulator of bone homeostasis through inhibition of the canonical Wnt-signaling pathway, and it is involved in the pathogenesis of many different skeletal diseases. Many studies have been published in the last few years regarding sclerostin's origi...

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Bibliographic Details
Published in:Journal of clinical medicine 2022-02, Vol.11 (3), p.806
Main Authors: Vasiliadis, Elias S, Evangelopoulos, Dimitrios-Stergios, Kaspiris, Angelos, Benetos, Ioannis S, Vlachos, Christos, Pneumaticos, Spyros G
Format: Article
Language:English
Subjects:
Antibodies
Apoptosis
Clinical medicine
Disease
Estrogens
Gene expression
Growth factors
Kinases
Ligands
Osteoporosis
Pathogenesis
Review
Womens health
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Summary:Sclerostin has been identified as an important regulator of bone homeostasis through inhibition of the canonical Wnt-signaling pathway, and it is involved in the pathogenesis of many different skeletal diseases. Many studies have been published in the last few years regarding sclerostin's origin, regulation, and mechanism of action. The ongoing research emphasizes the potential therapeutic implications of sclerostin in many pathological conditions with or without skeletal involvement. Antisclerostin antibodies have recently been approved for the treatment of osteoporosis, and several animal studies and clinical trials are currently under way to evaluate the effectiveness of antisclerostin antibodies in the treatment of other than osteoporosis skeletal disorders and cancer with promising results. Understanding the exact role of sclerostin may lead to new therapeutic approaches for the treatment of skeletal disorders.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm11030806