Small Differences in Vitamin D Levels between Male Cardiac Patients in Different Stages of Coronary Artery Disease

Cardiovascular diseases are the main cause of mortality in males older than 65 years of age. The prevalent vitamin D deficiency in the worldwide population may have multiple effects on the cardiovascular system. This study sought to determine the association between serum levels of 25-hydroxyvitamin...

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Bibliographic Details
Published in:Journal of clinical medicine 2022-01, Vol.11 (3), p.779
Main Authors: Dziedzic, Ewelina A, Grant, William B, Sowińska, Izabela, Dąbrowski, Marek, Jankowski, Piotr
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Age
Atherosclerosis
Body mass index
Cardiology
Cardiovascular disease
Cardiovascular system
Cholesterol
Clinical medicine
Coronary vessels
Diabetes
Heart attacks
High density lipoprotein
Hospitalization
Hypertension
Lipoproteins
Males
Medical imaging
Population
Proteins
Regression analysis
Risk factors
Statistical analysis
Variance analysis
Vein & artery diseases
Vitamin D
Vitamin deficiency
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Summary:Cardiovascular diseases are the main cause of mortality in males older than 65 years of age. The prevalent vitamin D deficiency in the worldwide population may have multiple effects on the cardiovascular system. This study sought to determine the association between serum levels of 25-hydroxyvitamin D (25(OH)D) and the stage of coronary artery disease (CAD) in Polish male subjects. Additionally, subjects with a history of myocardial infarction (MI) were analyzed for potential differences in 25(OH)D levels in comparison with those diagnosed with stable CAD. The study was conducted prospectively in a group of 669 male patients subjected to coronarography examination. CAD stage was defined using the Coronary Artery Surgery Study Score. Patients without significant coronary lesions had significantly higher 25(OH)D levels than patients with single-, double-, or triple-vessel disease (median, 17 vs. 15 ng/mL; < 0.01). Significantly lower levels of 25(OH)D were apparent when MI was identified as the cause of the then-current hospitalization in comparison with stable CAD, as well as in patients with a history of MI; all of these cases had lower levels of 25(OH)D in comparison with patients with no such history. Male patients with single-, double-, or triple-vessel CAD, acute coronary syndrome, or a history of MI presented lower serum 25(OH)D.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm11030779