Applications of Phyto-Nanotechnology for the Treatment of Neurodegenerative Disorders

The strategies involved in the development of therapeutics for neurodegenerative disorders are very complex and challenging due to the existence of the blood-brain barrier (BBB), a closely spaced network of blood vessels and endothelial cells that functions to prevent the entry of unwanted substance...

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Bibliographic Details
Published in:Materials 2022-01, Vol.15 (3), p.804
Main Authors: Bhattacharya, Tanima, Soares, Giselle Amanda Borges E, Chopra, Hitesh, Rahman, Md Mominur, Hasan, Ziaul, Swain, Shasank S, Cavalu, Simona
Format: Article
Language:English
Subjects:
Alzheimer's disease
Bioinformatics
Blood vessels
Blood-brain barrier
Dopamine
Endothelial cells
Herbal medicine
Homeostasis
Illnesses
Infections
Nanoparticles
Nanotechnology
Nervous system
Neurological diseases
Neurons
Parkinson's disease
Pathophysiology
Potassium
Proteins
Review
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Summary:The strategies involved in the development of therapeutics for neurodegenerative disorders are very complex and challenging due to the existence of the blood-brain barrier (BBB), a closely spaced network of blood vessels and endothelial cells that functions to prevent the entry of unwanted substances in the brain. The emergence and advancement of nanotechnology shows favourable prospects to overcome this phenomenon. Engineered nanoparticles conjugated with drug moieties and imaging agents that have dimensions between 1 and 100 nm could potentially be used to ensure enhanced efficacy, cellular uptake, specific transport, and delivery of specific molecules to the brain, owing to their modified physico-chemical features. The conjugates of nanoparticles and medicinal plants, or their components known as nano phytomedicine, have been gaining significance lately in the development of novel neuro-therapeutics owing to their natural abundance, promising targeted delivery to the brain, and lesser potential to show adverse effects. In the present review, the promising application, and recent trends of combined nanotechnology and phytomedicine for the treatment of neurological disorders (ND) as compared to conventional therapies, have been addressed. Nanotechnology-based efforts performed in bioinformatics for early diagnosis as well as futuristic precision medicine in ND have also been discussed in the context of computational approach.
ISSN:1996-1944
1996-1944
DOI:10.3390/ma15030804