Helicobacter typhlonius sp. nov., a novel murine urease-negative Helicobacter species

Over the past decade, several Helicobacter species have been isolated from rodents. With the advent of PCR for the diagnosis of infectious agents, it has become clear that several previously uncharacterized Helicobacter species also colonize rodents. In this report, we describe a novel urease-negati...

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Bibliographic Details
Published in:Journal of clinical microbiology 2001-11, Vol.39 (11), p.3920-3926
Main Authors: FRANKLIN, Craig L, GORELICK, Peter L, RILEY, Lela K, DEWHIRST, Floyd E, LIVINGSTON, Robert S, WARD, Jerrold M, BECKWITH, Catherine S, FOX, James G
Format: Article
Language:English
Subjects:
Animals
Animals, Laboratory
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Bacteriology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Genes, rRNA
Helicobacter
Helicobacter - classification
Helicobacter - enzymology
Helicobacter - genetics
Helicobacter hepaticus
Helicobacter Infections - microbiology
Helicobacter Infections - veterinary
Helicobacter typhlonius
Human bacterial diseases
Infectious diseases
Interleukin-10 - genetics
Intestines - microbiology
Medical sciences
Mice
Mice, Inbred C57BL
Mice, Knockout
Microbiology
Molecular Sequence Data
RNA, Ribosomal, 16S - genetics
Rodent Diseases - microbiology
Sequence Analysis, DNA
Systematics
Urease - metabolism
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Summary:Over the past decade, several Helicobacter species have been isolated from rodents. With the advent of PCR for the diagnosis of infectious agents, it has become clear that several previously uncharacterized Helicobacter species also colonize rodents. In this report, we describe a novel urease-negative helicobacter, Helicobacter typhlonius sp. nov., which was isolated from colonies of laboratory mice independently by two laboratories. Infection of immunodeficient mice by this bacterium resulted in typhlocolitis similar to that observed with other helicobacter infections. H. typhlonius is genetically most closely related to H. hepaticus. Like H. hepaticus, it is a spiral bacterium with bipolar sheathed flagella. However, this novel species contains a large intervening sequence in its 16S rRNA gene and is biochemically distinct from H. hepaticus. Notably, H. typhlonius does not produce urease or H(2)S nor does it hydrolize indoxyl-acetate. Compared to other Helicobacter species that commonly colonize rodents, H. typhlonius was found to be less prevalent than H. hepaticus and H. rodentium but as prevalent as H. bilis. H. typhlonius joins a growing list of helicobacters that colonize mice and are capable of inducing enteric disease in various strains of immunodeficient mice.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.39.11.3920-3926.2001