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Erythrocyte Complement Receptor 1 Gene Polymorphisms and Neonatal Respiratory Distress Syndrome
Abstract To evaluate the role of erythrocyte complement receptor 1 ( ECR1 ) gene in the predisposition to respiratory distress syndrome (RDS), we studied 50 infants with RDS and 50 controls. Real-time polymerase chain reaction allelic discrimination analysis of A3650G (rs2274567) and genotyping of t...
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| Published in: | Journal of pediatric genetics (Birmingham, Ala.) Ala.), 2022-03, Vol.11 (1), p.015-021 |
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| container_issue | 1 |
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| container_title | Journal of pediatric genetics (Birmingham, Ala.) |
| container_volume | 11 |
| creator | Rabie, Walaa Al-Taweel, Ahmed Abuelhamd, Walaa A. Shahin, Walaa Nazeer, Marian Aly, Hany |
| description | Abstract
To evaluate the role of erythrocyte complement receptor 1 (
ECR1
) gene in the predisposition to respiratory distress syndrome (RDS), we studied 50 infants with RDS and 50 controls. Real-time polymerase chain reaction allelic discrimination analysis of A3650G (rs2274567) and genotyping of the alleles (HindIII) were performed. Allele L of HindIII restricted single nucleotide polymorphism (SNP) associated with the severity of RDS. Duration of oxygen and ventilation in genotypes AA and AG of A3650G SNP was longer than genotype GG (17.6 ± 19.4 and 8.6 ± 4.5 days,
p
= 0.01) and (8.9 ± 11.9 and 3.9 ± 3.53 days,
p
= 0.03), respectively. A3650G and HINDIII digested gene polymorphisms of
ECR1
may be of little importance for RDS. |
| doi_str_mv | 10.1055/s-0040-1717108 |
| format | article |
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To evaluate the role of erythrocyte complement receptor 1 (
ECR1
) gene in the predisposition to respiratory distress syndrome (RDS), we studied 50 infants with RDS and 50 controls. Real-time polymerase chain reaction allelic discrimination analysis of A3650G (rs2274567) and genotyping of the alleles (HindIII) were performed. Allele L of HindIII restricted single nucleotide polymorphism (SNP) associated with the severity of RDS. Duration of oxygen and ventilation in genotypes AA and AG of A3650G SNP was longer than genotype GG (17.6 ± 19.4 and 8.6 ± 4.5 days,
p
= 0.01) and (8.9 ± 11.9 and 3.9 ± 3.53 days,
p
= 0.03), respectively. A3650G and HINDIII digested gene polymorphisms of
ECR1
may be of little importance for RDS.</description><identifier>ISSN: 2146-4596</identifier><identifier>EISSN: 2146-460X</identifier><identifier>DOI: 10.1055/s-0040-1717108</identifier><identifier>PMID: 35186385</identifier><language>eng</language><publisher>Rüdigerstraße 14, 70469 Stuttgart, Germany: Georg Thieme Verlag KG</publisher><subject>Original ; Original Article</subject><ispartof>Journal of pediatric genetics (Birmingham, Ala.), 2022-03, Vol.11 (1), p.015-021</ispartof><rights>Thieme. All rights reserved.</rights><rights>Thieme. All rights reserved. 2020 Georg Thieme Verlag KG</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c313t-505990daad6592c79f05dd4d0ea85fa41e86368579df8f55da194e0b9c376ff93</cites><orcidid>0000-0001-7395-6394</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847060/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847060/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35186385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rabie, Walaa</creatorcontrib><creatorcontrib>Al-Taweel, Ahmed</creatorcontrib><creatorcontrib>Abuelhamd, Walaa A.</creatorcontrib><creatorcontrib>Shahin, Walaa</creatorcontrib><creatorcontrib>Nazeer, Marian</creatorcontrib><creatorcontrib>Aly, Hany</creatorcontrib><title>Erythrocyte Complement Receptor 1 Gene Polymorphisms and Neonatal Respiratory Distress Syndrome</title><title>Journal of pediatric genetics (Birmingham, Ala.)</title><addtitle>J Pediatr Genet</addtitle><description>Abstract
To evaluate the role of erythrocyte complement receptor 1 (
ECR1
) gene in the predisposition to respiratory distress syndrome (RDS), we studied 50 infants with RDS and 50 controls. Real-time polymerase chain reaction allelic discrimination analysis of A3650G (rs2274567) and genotyping of the alleles (HindIII) were performed. Allele L of HindIII restricted single nucleotide polymorphism (SNP) associated with the severity of RDS. Duration of oxygen and ventilation in genotypes AA and AG of A3650G SNP was longer than genotype GG (17.6 ± 19.4 and 8.6 ± 4.5 days,
p
= 0.01) and (8.9 ± 11.9 and 3.9 ± 3.53 days,
p
= 0.03), respectively. A3650G and HINDIII digested gene polymorphisms of
ECR1
may be of little importance for RDS.</description><subject>Original</subject><subject>Original Article</subject><issn>2146-4596</issn><issn>2146-460X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kU1LxDAQhoMoKrpXj5Kjl2rSNGlyEWRdP0BU_ABvITZTt9I2NckK_fdm2VX04OQwA3nyzmRehA4oOaaE85OQEVKQjJbpELmBdnNaiKwQ5GXzu-ZK7KBJCO8kRUlZruQ22mGcSsEk30V65sc4964aI-Cp64YWOugjfoAKhug8pvgSesD3rh0754d5E7qATW_xLbjeRNMmNAyNNwke8XkToocQ8OPYW-862EdbtWkDTNZ5Dz1fzJ6mV9nN3eX19OwmqxhlMeOEK0WsMVZwlVelqgm3trAEjOS1KSikeYXkpbK1rDm3hqoCyKuqWCnqWrE9dLrSHRavHdgq_cGbVg--6YwftTON_nvTN3P95j61lEVJBEkCR2sB7z4WEKLumlBB25oe3CLoXDAq8jxXLKHHK7TyLgQP9U8bSvTSGB300hi9NiY9OPw93A_-bUMCshUQ503av353C9-ndf0n-AU305ko</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Rabie, Walaa</creator><creator>Al-Taweel, Ahmed</creator><creator>Abuelhamd, Walaa A.</creator><creator>Shahin, Walaa</creator><creator>Nazeer, Marian</creator><creator>Aly, Hany</creator><general>Georg Thieme Verlag KG</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7395-6394</orcidid></search><sort><creationdate>20220301</creationdate><title>Erythrocyte Complement Receptor 1 Gene Polymorphisms and Neonatal Respiratory Distress Syndrome</title><author>Rabie, Walaa ; Al-Taweel, Ahmed ; Abuelhamd, Walaa A. ; Shahin, Walaa ; Nazeer, Marian ; Aly, Hany</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-505990daad6592c79f05dd4d0ea85fa41e86368579df8f55da194e0b9c376ff93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Original</topic><topic>Original Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rabie, Walaa</creatorcontrib><creatorcontrib>Al-Taweel, Ahmed</creatorcontrib><creatorcontrib>Abuelhamd, Walaa A.</creatorcontrib><creatorcontrib>Shahin, Walaa</creatorcontrib><creatorcontrib>Nazeer, Marian</creatorcontrib><creatorcontrib>Aly, Hany</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of pediatric genetics (Birmingham, Ala.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rabie, Walaa</au><au>Al-Taweel, Ahmed</au><au>Abuelhamd, Walaa A.</au><au>Shahin, Walaa</au><au>Nazeer, Marian</au><au>Aly, Hany</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Erythrocyte Complement Receptor 1 Gene Polymorphisms and Neonatal Respiratory Distress Syndrome</atitle><jtitle>Journal of pediatric genetics (Birmingham, Ala.)</jtitle><addtitle>J Pediatr Genet</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>11</volume><issue>1</issue><spage>015</spage><epage>021</epage><pages>015-021</pages><issn>2146-4596</issn><eissn>2146-460X</eissn><abstract>Abstract
To evaluate the role of erythrocyte complement receptor 1 (
ECR1
) gene in the predisposition to respiratory distress syndrome (RDS), we studied 50 infants with RDS and 50 controls. Real-time polymerase chain reaction allelic discrimination analysis of A3650G (rs2274567) and genotyping of the alleles (HindIII) were performed. Allele L of HindIII restricted single nucleotide polymorphism (SNP) associated with the severity of RDS. Duration of oxygen and ventilation in genotypes AA and AG of A3650G SNP was longer than genotype GG (17.6 ± 19.4 and 8.6 ± 4.5 days,
p
= 0.01) and (8.9 ± 11.9 and 3.9 ± 3.53 days,
p
= 0.03), respectively. A3650G and HINDIII digested gene polymorphisms of
ECR1
may be of little importance for RDS.</abstract><cop>Rüdigerstraße 14, 70469 Stuttgart, Germany</cop><pub>Georg Thieme Verlag KG</pub><pmid>35186385</pmid><doi>10.1055/s-0040-1717108</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-7395-6394</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8847060 |
| source | Open Access: PubMed Central |
| subjects | Original Original Article |
| title | Erythrocyte Complement Receptor 1 Gene Polymorphisms and Neonatal Respiratory Distress Syndrome |
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