High virucidal potential of novel ceramic–metal composites fabricated via hybrid selective laser melting and spark plasma sintering routes

In this work, we combine selective laser melting (SLM) and spark plasma sintering (SPS) to fabricate new materials with high virucidal potential. Various bioactive disc-shaped ceramics, metal alloys, and composites were fabricated and tested against bacteriophage Phi6—a model system for RNA-envelope...

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Bibliographic Details
Published in:International journal of advanced manufacturing technology 2022, Vol.120 (1-2), p.975-988
Main Authors: Rahmani, Ramin, Molan, Katja, Brojan, Miha, Prashanth, Konda Gokuldoss, Stopar, David
Format: Article
Language:English
Subjects:
Biological activity
CAE) and Design
Ceramic powders
Ceramics
Composite materials
Computer-Aided Engineering (CAD
Copper
Engineering
Industrial and Production Engineering
Laser beam melting
Lattices
Mechanical Engineering
Media Management
Metal powders
Original
Original Article
Phages
Plasma sintering
Rapid prototyping
Silver
Sintering (powder metallurgy)
Spark plasma sintering
Three dimensional printing
Titanium
Titanium dioxide
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Summary:In this work, we combine selective laser melting (SLM) and spark plasma sintering (SPS) to fabricate new materials with high virucidal potential. Various bioactive disc-shaped ceramics, metal alloys, and composites were fabricated and tested against bacteriophage Phi6—a model system for RNA-enveloped viruses. We prepared silver-doped titanium dioxide (TiO 2  + 2.5‒10% Ag), copper-doped titanium dioxide (TiO 2  + 2.5‒10% Cu), Cu2NiSiCr, and Cu15Ni8Sn composite materials (metal lattices filled with ceramics). The virucidal tests of the ceramic and metal powders were performed in buffered suspensions, while the surfaces of the discs were tested by swabbing. The results show that the virus titer on the TiO 2  + 10% Ag ceramic and CuNi2SiCr metal discs decreased by 4 logs after 15 min of exposure to the surfaces compared to the control ceramic and steel discs. We show that SLM 3D printed pre-alloyed CuNi2SiCr filled with bioactive TiO 2  + 10% Ag nanopowders and sintered by the SPS process combines the simplicity of printing with the strength and virucidal properties of Ag and Cu materials. The proposed new virucidal materials were also used for the fabrication of prototype elevator buttons.
ISSN:0268-3768
1433-3015
DOI:10.1007/s00170-022-08878-x