Prechoroidal cleft thickness correlates with disease activity in neovascular age-related macular degeneration

Purpose The purpose of this study was to investigate the structural variations of the hyporeflective pocket of fluid (prechoroidal cleft) located between Bruch’s membrane and the hyperreflective material within the pigment epithelial detachment (PED) in patients with neovascular age-related macular...

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Published in:Graefe's archive for clinical and experimental ophthalmology 2022-03, Vol.260 (3), p.781-789
Main Authors: Cozzi, Mariano, Monteduro, Davide, Parrulli, Salvatore, Ristoldo, Federica, Corvi, Federico, Zicarelli, Federico, Staurenghi, Giovanni, Invernizzi, Alessandro
Format: Article
Language:English
Subjects:
Acuity
Age
Angiogenesis Inhibitors - therapeutic use
Fluorescein Angiography
Humans
Intravitreal Injections
Macular degeneration
Macular Degeneration - diagnosis
Medicine
Medicine & Public Health
Multivariate analysis
Ophthalmology
Patients
Retinal Disorders
Retinal Pigment Epithelium
Retrospective Studies
Tomography, Optical Coherence
Vascular endothelial growth factor
Vascularization
Wet Macular Degeneration - complications
Wet Macular Degeneration - diagnosis
Wet Macular Degeneration - drug therapy
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Summary:Purpose The purpose of this study was to investigate the structural variations of the hyporeflective pocket of fluid (prechoroidal cleft) located between Bruch’s membrane and the hyperreflective material within the pigment epithelial detachment (PED) in patients with neovascular age-related macular degeneration (nAMD). Methods In this retrospective, observational case series study, patients diagnosed with nAMD and prechoroidal cleft associated with other activity signs of the macular neovascularization (MNV) were included. Structural optical coherence tomography (OCT) scans were evaluated to obtain anatomical measurements of prechoroidal cleft and PED at three different visits (T0, inactive MNV; T1, active MNV; T2, treated inactive MNV). The variations in size of the cleft and the PED were correlated with nAMD activity. Results Twenty-nine eyes from 27 patients were included. The subfoveal measurements showed a significant increase of prechoroidal cleft height and width from T0 to T1 ( P  
ISSN:0721-832X
1435-702X
DOI:10.1007/s00417-021-05384-w