Brief report on the HMGB1-antagonism exerted by glycyrrhizin could be fruitful against COVID-19

The COVID-19 pandemic era is causing a relevant issue for the health. There is no specific drug able to antagonize the SARS-CoV-2 infection. As a consequence, there is growing interest about potential molecules able to contrast infection. In this regard, HMGB, an alarmin, may play a relevant role in...

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Published in:Acta bio-medica de l'Ateneo Parmense 2021-10, Vol.92 (Suppl 6)
Main Authors: Ciprandi, Giorgio, Bellussi, Luisa Maria, Damiani, Valerio, Passali, Desiderio
Format: Article
Language:English
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Summary:The COVID-19 pandemic era is causing a relevant issue for the health. There is no specific drug able to antagonize the SARS-CoV-2 infection. As a consequence, there is growing interest about potential molecules able to contrast infection. In this regard, HMGB, an alarmin, may play a relevant role in pathogenic mechanisms induced by SARS-CoV-2. As HMGB1 is antagonized by glycyrrhizin, this substance could be potentially useful as ancillary treatment in COVID-19. ( www.actabiomedica.it )
ISSN:0392-4203
2531-6745
DOI:10.23750/abm.v92iS6.12111