Targeting the P53 Protein for Cancer Therapies: The Translational Impact of P53 Research

It is only recently that drugs targeting K-RAS and Tp53 missense mutations have been developed, and along with the allele specific nature of some of these drugs comes the possibility of combining them with the immunologic therapies for cancers. It has taken about 40 years since their discoveries to...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2022-02, Vol.82 (3), p.362-364
Main Author: Levine, Arnold J
Format: Article
Language:English
Subjects:
Humans
Mutation
Neoplasms - genetics
Tumor Suppressor Protein p53 - genetics
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Summary:It is only recently that drugs targeting K-RAS and Tp53 missense mutations have been developed, and along with the allele specific nature of some of these drugs comes the possibility of combining them with the immunologic therapies for cancers. It has taken about 40 years since their discoveries to understand the pathways they command, how they function, and how they interact with the environment of the cells they control. This communication focuses on the transfer of some of the hard won information about the p53 protein, its mutations, structures, and activities learned in the basic science laboratory and translated to the clinic.
ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.CAN-21-2709