Carotid Artery Stiffness Mechanisms Associated With Cardiovascular Disease Events and Incident Hypertension: the Multi-Ethnic Study of Atherosclerosis (MESA)

Elastic arteries stiffen via 2 main mechanisms: (1) load-dependent stiffening from higher blood pressure and (2) structural stiffening due to changes in the vessel wall. It is unknown how these different mechanisms contribute to incident cardiovascular disease (CVD) events. The MESA (Multi-Ethnic St...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2022-03, Vol.79 (3), p.659-666
Main Authors: Pewowaruk, Ryan J., Korcarz, Claudia, Tedla, Yacob, Burke, Gregory, Greenland, Philip, Wu, Colin, Gepner, Adam D.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Atherosclerosis - diagnostic imaging
Atherosclerosis - physiopathology
Blood Pressure - physiology
Cardiovascular Diseases - diagnostic imaging
Cardiovascular Diseases - physiopathology
Carotid Arteries - diagnostic imaging
Carotid Arteries - physiopathology
Female
Humans
Hypertension - diagnostic imaging
Hypertension - epidemiology
Hypertension - physiopathology
Incidence
Longitudinal Studies
Male
Middle Aged
Ultrasonography
Vascular Stiffness - physiology
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Summary:Elastic arteries stiffen via 2 main mechanisms: (1) load-dependent stiffening from higher blood pressure and (2) structural stiffening due to changes in the vessel wall. It is unknown how these different mechanisms contribute to incident cardiovascular disease (CVD) events. The MESA (Multi-Ethnic Study of Atherosclerosis) is a longitudinal study of 6814 men and women without CVD at enrollment, from 6 communities in the United States. MESA participants with B-mode carotid ultrasound and brachial blood pressure at baseline Exam in (2000-2002) and CVD surveillance (mean follow-up 14.3 years through 2018) were included (n=5873). Peterson's elastic modulus was calculated to represent total arterial stiffness. Structural stiffness was calculated by adjusting Peterson's elastic modulus to a standard blood pressure of 120/80 mm Hg with participant-specific models. Load-dependent stiffness was the difference between total and structural stiffness. In Cox models adjusted for traditional risk factors, load-dependent stiffness was significantly associated with higher incidence of CVD events (hazard ratio/100 mm Hg, 1.21 [95% CI, 1.09-1.34]
ISSN:0194-911X
1524-4563
1524-4563
DOI:10.1161/HYPERTENSIONAHA.121.18772