Circadian regulation of innate immunity in animals and humans and implications for human disease

Circadian rhythms are 24-h oscillating variations in physiology generated by the core circadian clock. There is now a wide body of evidence showing circadian regulation of the immune system. Innate immune cells contain the molecular circadian clock which drives rhythmic responses, from the magnitude...

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Bibliographic Details
Published in:Seminars in immunopathology 2022-03, Vol.44 (2), p.183-192
Main Authors: Poole, Joanna, Kitchen, Gareth B.
Format: Article
Language:English
Subjects:
Animals
Asthma - etiology
Biomedical and Life Sciences
Biomedicine
Circadian Clocks - physiology
Circadian Rhythm - physiology
Humans
Immune System
Immunity, Innate
Immunology
Internal Medicine
Pathology
Review
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Summary:Circadian rhythms are 24-h oscillating variations in physiology generated by the core circadian clock. There is now a wide body of evidence showing circadian regulation of the immune system. Innate immune cells contain the molecular circadian clock which drives rhythmic responses, from the magnitude of the inflammatory response to the numbers of circulating immune cells varying throughout the day. This leads to rhythmic presentation of disease clinically, for example the classic presentation of nocturnal asthma or the sudden development of pulmonary oedema from acute myocardial infarction first thing in the morning.
ISSN:1863-2297
1863-2300
1863-2300
DOI:10.1007/s00281-022-00921-z