Edema in childhood nephrotic syndrome: possible genes–hormones interplay

Background The role of atrial natriuretic peptide (ANP) in edema formation in idiopathic nephrotic syndrome (INS) was studied before with conflicting results reported; however, the possible contribution of genes regulating ANP expression and receptors was never explored. Methods One hundred children...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Genetic Engineering and Biotechnology 2022-02, Vol.20 (1), p.30-8, Article 30
Main Authors: El-Halaby, Hanan, Bakr, Ashraf, Eid, Riham, Abdalla, Hussein Abdelaziz, Hamdy, Nashwa, Shamekh, Nora, Adel, Amira
Format: Article
Language:English
Subjects:
Atrial natriuretic peptide
Children
Comparative analysis
Dropsy
Edema
Gene polymorphisms
Genes
Genetic aspects
Genetic polymorphisms
Genetic research
Medical research
Medicine, Experimental
Natriuretic peptides
Nephrotic syndrome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background The role of atrial natriuretic peptide (ANP) in edema formation in idiopathic nephrotic syndrome (INS) was studied before with conflicting results reported; however, the possible contribution of genes regulating ANP expression and receptors was never explored. Methods One hundred children (60 with active INS and 40 in remission) were studied for plasma atrial natriuretic peptide (ANP), urinary sodium, ANP gene A2843G and ScaI polymorphisms, and natriuretic peptide receptor clearance C (-55) A polymorphism. For comparative purposes, 20 healthy controls were studied for ANP levels. Results ANP was higher in active compared to remission patients (p
ISSN:1687-157X
2090-5920
DOI:10.1186/s43141-022-00310-x