Protein metalation in biology

Inorganic metals supplement the chemical repertoire of organic molecules, especially proteins. This requires the correct metals to associate with proteins at metalation. Protein mismetalation typically occurs when excesses of unbound metals compete for a binding site ex vivo. However, in biology, ex...

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Bibliographic Details
Published in:Current opinion in chemical biology 2022-02, Vol.66, p.102095-102095, Article 102095
Main Authors: Foster, Andrew W., Young, Tessa R., Chivers, Peter T., Robinson, Nigel J.
Format: Article
Language:English
Subjects:
Biology
Cobalt
Cobalt - metabolism
Copper
Copper - metabolism
Iron
Magnesium
Manganese
Manganese - chemistry
Metal availability
Metal sensors
Metal specificity
Metalation calculator
Metals - metabolism
Nickel
Zinc
Zinc - metabolism
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Summary:Inorganic metals supplement the chemical repertoire of organic molecules, especially proteins. This requires the correct metals to associate with proteins at metalation. Protein mismetalation typically occurs when excesses of unbound metals compete for a binding site ex vivo. However, in biology, excesses of metal-binding sites typically compete for limiting amounts of exchangeable metals. Here, we summarise mechanisms of metal homeostasis that sustain optimal metal availabilities in biology. We describe recent progress to understand metalation by comparing the strength of metal binding to a protein versus the strength of binding to competing sites inside cells.
ISSN:1367-5931
1879-0402
DOI:10.1016/j.cbpa.2021.102095