VISTA in Soft Tissue Sarcomas: A Perspective for Immunotherapy?

(1) Background: V domain immunoglobulin suppressor of T cell activation (VISTA) plays a critical role in antitumor immunity and may be a valuable target in cancer immunotherapy. To date, it has never been studied in a large and well-characterised cohort of soft tissue sarcomas (STS). (2) Methods: Us...

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Published in:Cancers 2022-02, Vol.14 (4), p.1006
Main Authors: Albertsmeier, Markus, Altendorf-Hofmann, Annelore, Lindner, Lars H, Issels, Rolf D, Kampmann, Eric, Dürr, Hans-Roland, Angele, Martin K, Klauschen, Frederick, Werner, Jens, Jungbluth, Achim A, Knösel, Thomas
Format: Article
Language:English
Subjects:
Antibodies
Apoptosis
Biopsy
Cancer immunotherapy
CD3 antigen
Cell activation
Chemotherapy
Heat
Hyperthermia
Immunohistochemistry
Immunotherapy
Inflammation
Laboratories
Liposarcoma
Lymphocytes T
Medical prognosis
Metastasis
Multivariate analysis
Pathology
PD-1 protein
PD-L1 protein
Radiation therapy
Regression analysis
Sarcoma
Soft tissue sarcoma
Statistical analysis
Surgical outcomes
Tumors
Variance analysis
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Summary:(1) Background: V domain immunoglobulin suppressor of T cell activation (VISTA) plays a critical role in antitumor immunity and may be a valuable target in cancer immunotherapy. To date, it has never been studied in a large and well-characterised cohort of soft tissue sarcomas (STS). (2) Methods: Using immunohistochemistry, we examined VISTA expression in tumour tissues of 213 high-risk STS. We then analysed whether VISTA was associated with other clinicopathological parameters, including tumour-infiltrating lymphocyte (TIL) counts, programmed death receptor-1 (PD1), programmed death ligand-1 (PDL1), CD3, grading, and long-term survival. (3) Results: We observed VISTA expression in 96 (45%) of 213 specimens with distinct patterns ranging from 26 to 63% for histological subtypes. VISTA was associated with higher grade (G3 vs. G2, = 0.019), higher TIL counts ( = 0.033), expression of PD1 ( = 0.046), PDL1 ( = 0.031), and CD3+ ( = 0.023). In patients without CD3 TILs, 10-year survival was higher when VISTA was expressed compared to when there was no VISTA expression ( = 0.013). In a multivariate analysis, VISTA expression was independently associated with prolonged survival ( = 0.043). (4) Conclusions: VISTA is expressed in different STS subtypes and is associated with increased TILs, PD-1, PD-L1, and CD3 expression. Patients with VISTA tumours show improved survival. These results may help define future immunotherapeutic approaches in STS.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers14041006