The Dynamic Behavior of Chromatin in Response to DNA Double-Strand Breaks

The primary functions of the eukaryotic nucleus as a site for the storage, retrieval, and replication of information require a highly dynamic chromatin organization, which can be affected by the presence of DNA damage. In response to double-strand breaks (DSBs), the mobility of chromatin at the brea...

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Bibliographic Details
Published in:Genes 2022-01, Vol.13 (2), p.215
Main Authors: García Fernández, Fabiola, Fabre, Emmanuelle
Format: Article
Language:English
Subjects:
Cell cycle
Chromatin
Chromatin - genetics
Chromosomes
CRISPR
Cyclin-dependent kinases
Deoxyribonucleic acid
DNA
DNA Breaks, Double-Stranded
DNA Damage
DNA Repair - genetics
Genomes
Kinases
Life Sciences
Mammals
Mobility
Phosphorylation
Proteins
Review
Yeast
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Summary:The primary functions of the eukaryotic nucleus as a site for the storage, retrieval, and replication of information require a highly dynamic chromatin organization, which can be affected by the presence of DNA damage. In response to double-strand breaks (DSBs), the mobility of chromatin at the break site is severely affected and, to a lesser extent, that of other chromosomes. The how and why of such movement has been widely studied over the last two decades, leading to different mechanistic models and proposed potential roles underlying both local and global mobility. Here, we review the state of the knowledge on current issues affecting chromatin mobility upon DSBs, and highlight its role as a crucial step in the DNA damage response (DDR).
ISSN:2073-4425
2073-4425
DOI:10.3390/genes13020215